RUNX2


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Related to RUNX2: RUNX1

RUNX2

A gene on chromosome 6p21 that encodes a nuclear protein member of the RUNX family of transcription factors with a Runt DNA-binding domain. RUNX2 is essential for osteoblastic differentiation and skeletal morphogenesis, and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.

Molecular pathology
RUNX2 mutations cause cleidocranial dysplasia, a bone development disorder.
References in periodicals archive ?
Runx2, Osterix, and b-catenin are the vital transcription factors for osteoblast differentiation (6).
Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.
The direct fabrication of graphene on NiTi based dental implant using chemical vapor deposition technique upregulated the expression level of osteogenic related genes (OCN, OPN, BMP-2, and RUNX2) and promoted expression of integrin [beta]1 and initial adhesion of MSCs, indicating that graphene-functionalized NiTi allows better MSCs cytoskeleton development and spontaneous osteogenic differentiation [66].
Komori, "Roles of Runx2 in skeletal development," Advances in Experimental Medicine and Biology, vol.
In Vivo Immunohistochemical Analyses of the Expression of Dkk-1, PPAR[gamma], GSK-3[beta], Runx2, and [beta]-Catenin in the Femoral Head.
Osteogenic differentiation-related genes RUNX2, OPN, and OCN were detected after MSCs were cultured for different periods.
Meanwhile, our data also indicated that Runx2 protein may be involved in the effect of [gamma]-tocotrienol on bone formation through osteoblastic differentiation and subsequent mineralization.
Wei et al., "A novel Alu-mediated microdeletion in the RUNX2 gene in a Chinese patient with cleidocranial dysplasia," Journal of Genetics, vol.
Conversely, miR-133 is involved in inhibiting osteoblast differentiation, through the downregulation of Runx2 expression, a downstream effector of Wnt signaling pathway [57].
PCR was performed using a real-time PCR kit (SYBR Premix Ex Taq II, TaKaRa) to detect osteopontin (OPN), osteocalcin (OC), bone sialoprotein (BSP), Runx2, and type I collagen (COL-I) mRNA on a Light Cycler 480 II (Roche, Germany).
The membranes were blocked and incubated with antibodies against Beclin1, SQSTM1/p62 (Abcam, USA), bone morphogenetic protein 2 (BMP-2), runt-related transcription factor 2 (Runx2), [beta]-actin (Immunoway, USA), and LC3B antibody (CST, USA).
SATB2 has also been shown to have a role in osteoblast differentiation via interactions with transcriptional regulator Runx2 and a microRNA network.