RUNX2


Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.
Related to RUNX2: RUNX1

RUNX2

A gene on chromosome 6p21 that encodes a nuclear protein member of the RUNX family of transcription factors with a Runt DNA-binding domain. RUNX2 is essential for osteoblastic differentiation and skeletal morphogenesis, and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.

Molecular pathology
RUNX2 mutations cause cleidocranial dysplasia, a bone development disorder.
Mentioned in ?
References in periodicals archive ?
Runx2, Osterix, and b-catenin are the vital transcription factors for osteoblast differentiation (6).
MicroRNA-221 promotes cell proliferation, migration, and differentiation by regulation of ZFPM2 in osteoblasts
Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.
Research Progress on the Relationship between Coronary Artery Calcification and Chronic Renal Failure
The direct fabrication of graphene on NiTi based dental implant using chemical vapor deposition technique upregulated the expression level of osteogenic related genes (OCN, OPN, BMP-2, and RUNX2) and promoted expression of integrin [beta]1 and initial adhesion of MSCs, indicating that graphene-functionalized NiTi allows better MSCs cytoskeleton development and spontaneous osteogenic differentiation [66].
Graphene Family Nanomaterials: Properties and Potential Applications in Dentistry
Komori, "Roles of Runx2 in skeletal development," Advances in Experimental Medicine and Biology, vol.
Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients
In Vivo Immunohistochemical Analyses of the Expression of Dkk-1, PPAR[gamma], GSK-3[beta], Runx2, and [beta]-Catenin in the Femoral Head.
Efficiency of Cell Therapy to GC-Induced ONFH: BMSCs with Dkk-1 Interference Is Not Superior to Unmodified BMSCs. (Research Article)
Osteogenic differentiation-related genes RUNX2, OPN, and OCN were detected after MSCs were cultured for different periods.
Effects of Type 2 Diabetic Serum on Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells
Meanwhile, our data also indicated that Runx2 protein may be involved in the effect of [gamma]-tocotrienol on bone formation through osteoblastic differentiation and subsequent mineralization.
Gamma-Tocotrienol Stimulates the Proliferation, Differentiation, and Mineralization in Osteoblastic MC3T3-E1 Cells
Wei et al., "A novel Alu-mediated microdeletion in the RUNX2 gene in a Chinese patient with cleidocranial dysplasia," Journal of Genetics, vol.
The Treatment of Cleidocranial Dysostosis (Scheuthauer-Marie-Sainton Syndrome), a Rare Form of Skeletal Dysplasia, Accompanied by Spinal Deformities: A Review of the Literature and Two Case Reports
Conversely, miR-133 is involved in inhibiting osteoblast differentiation, through the downregulation of Runx2 expression, a downstream effector of Wnt signaling pathway [57].
The Potential Role of miRNAs as New Biomarkers for Osteoporosis
PCR was performed using a real-time PCR kit (SYBR Premix Ex Taq II, TaKaRa) to detect osteopontin (OPN), osteocalcin (OC), bone sialoprotein (BSP), Runx2, and type I collagen (COL-I) mRNA on a Light Cycler 480 II (Roche, Germany).
Icariin-Loaded Ti[O.sub.2] Nanotubes for Regulation of the Bioactivity of Bone Marrow Cells
The membranes were blocked and incubated with antibodies against Beclin1, SQSTM1/p62 (Abcam, USA), bone morphogenetic protein 2 (BMP-2), runt-related transcription factor 2 (Runx2), [beta]-actin (Immunoway, USA), and LC3B antibody (CST, USA).
Activation of CD137 Signaling Enhances Vascular Calcification through c-Jun N-Terminal Kinase-Dependent Disruption of Autophagic Flux
SATB2 has also been shown to have a role in osteoblast differentiation via interactions with transcriptional regulator Runx2 and a microRNA network.
SATB2 as an Immunohistochemical Marker for Colorectal Adenocarcinoma: A Concise Review of Benefits and Pitfalls

Medical browser ?
Full browser ?