Rosenthal fiber

Ro·sen·thal fi·ber

an oval or elongated eosinophilic mass believed to represent a modified process of an astrocyte; seen in large numbers in certain slowly growing astrocytomas and areas of chronic reactive gliosis.
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Most PAs harbor Rosenthal fibers within their compact or fibrillary areas.
Eosinophilic granular bodies may also be present but are often fewer than Rosenthal fibers (Figure 2a-2d).
PMAs lack Rosenthal fibers and a biphasic pattern and exceptionally demonstrate rare eosinophilic granular bodies.
Recent Progress in the Pathology and Genetics of Pilocytic and Pilomyxoid Astrocytomas
Both models exhibit disease-associated protein deposits called Rosenthal fibers.
A Stem Cell Model To Test Treatments For Rare Nervous System Disorder
There was a well-defined fibrillary glial proliferation, with occasional fragments of Rosenthal fibers similar to that seen in a pilocytic astrocytoma (Figure 2(a)).
(a) The tumor has a fibrillary glial background with occasional Rosenthal fibers (arrows).
Suprasellar Ganglioglioma: Expanding the Differential Diagnosis
(1) Alexander disease is a rare leukodystrophy characterized by astrocytic cytoplasmic inclusions called Rosenthal fibers. Most cases are attributed to a mutation of the GFAP (glial fibrillary acidic protein) gene, which causes abnormal function or gain of function in the GFAP.
MRS findings in a patient with juvenile-onset Alexander's leukodystrophy
No eosinophilic granular bodies, Rosenthal fibers, or Herring bodies were identified within the tumors.
Pituicytoma: characterization of a unique neoplasm by histology, immunohistochemistry, ultrastructure, and array-based comparative genomic hybridization
In contrast to PA, Rosenthal fibers, eosinophilic granular bodies and calcifications tend to be absent or uncommon in PMA, though Gottfired et al., described a PMA case with Rosenthal fibers, and microcalcifications (5).
Pilomyxoid astrocytoma in unusual location in a child with neurofibromatosis type 1: case report and review of the literature
No Verocay bodies, thick-walled blood vessels, Rosenthal fibers, granular bodies, calcifications, or psammoma bodies were present.
In contrast with pilocytic astrocytomas, pituicytomas lack Rosenthal fibers, granular bodies, and biphasic morphologic structure.
Intrasellar Pituicytoma in a Patient With Other Endocrine Neoplasms

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