Rosai-Dorfman disease

si·nus his·ti·o·cy·to·sis with mas·sive lym·phad·e·nop·a·thy

a chronic disease occurring in children and characterized by massive painless cervical lymphadenopathy due to distension of the lymphatic sinuses by macrophages containing ingested lymphocytes, and by capsular and pericapsular fibrosis.

Rosai-Dorfman disease

(rō′zī-dôrf′măn′, -mən)
n.
A chronic disease characterized by painless, massively enlarged cervical lymph nodes whose sinuses contain histiocytes that have engulfed lymphocytes and other cells. Extranodal involvement sometimes occurs.

Rosai-Dorfman disease

A rare, benign idiopathic condition characterised by bilateral cervical lymphadenopathy. It is most common in young black men and women, but may affect other ages and races; it may be extranodal. 

Clinical findings
Massive bilateral cervical lymphadenopathy, fever.

Lab
Leukocytosis, increased erythrocyte sedimentation rate, polyclonal hyperimmunoglobulinaemia.
 
Prognosis
Uncertain; most resolve spontaneously, but some are aggressive and ultimately fatal.

si·nus his·ti·o·cy·to·sis with mas·sive lym·phad·e·nop·a·thy

(sī'nŭs his'tē-ō-sī-tō'sis mas'iv limf-ad-ĕ-nop'ă-thē)
A chronic disease occurring in children characterized by massive painless cervical lymphadenopathy due to distension of the lymphatic sinuses by macrophages containing ingested lymphocytes, and by capsular and pericapsular fibrosis.
Synonym(s): Rosai-Dorfman disease.

Rosai,

Juan, U.S. pathologist, 1941–.
Rosai-Dorfman disease - Synonym(s): sinus histiocytosis with massive lymphadenopathy
References in periodicals archive ?
Keywords: Sinus histiocytosis with massive lymphadenopathy, Rosai-Dorfman disease, Ascites.
Q Our granddaughter has been diagnosed with Rosai-Dorfman disease (RD).
Given the morphologic appearance of Mikulicz cells, one must consider various histiocytic lesions, such as Rosai-Dorfman disease and Erdheim-Chester disease.
Differential diagnosis for extra-axial dural based mass lesions includes metastatic disease, hemangiopericytoma, lymphoma, solitary fibrous tumor, and Rosai-Dorfman Disease, among others.
Background: Rosai-Dorfman disease (RDD) is typically characterized by painless bilateral and symmetrical cervical lymphadenopathy, with associated fever and leukocytosis.
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare, nonmalignant histiocytic proliferative disease first described in 1969[1].
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy (SHML), is a disease of benign histiocytic proliferation of unknown etiology [1, 2].
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare nonmalignant lymphohistiocytic proliferative disorder, described for the first time by Rosai and Dorfman in 1969 [1].
Rosai-Dorfman disease, first described in 1969, is a nonneoplastic histiocytic proliferative disorder of unknown etiology and pathogenesis [1].
Rosai-Dorfman disease (RDD) was named after Rosai and Dorfman, who were the first to describe the illness in 1969 [1].
Rosai-Dorfman disease (RDD), otherwise known as sinus histiocytosis with massive lymphadenopathy (SHML), is a rare and benign histiocytic proliferative disorder of unknown aetiology.
A single case of Rosai-Dorfman disease marked by pathological fractures, kidney failure, and liver cirrhosis treated by a single agent cladribine.