Romano-Ward syndrome

(redirected from Romano-ward)

Romano-Ward syndrome

 [ro-mah´no ward´]
prolongation of the Q–T interval with syncope, sometimes with ventricular fibrillation and sudden death; it is inherited as an autosomal dominant trait and can be triggered by stress or exercise. See also long QT syndrome.

Ro·ma·no-Ward syn·drome

(rō-mahn'ō wărd), [MIM*192500]
a prolonged QT interval in the electrocardiogram in children subject to attacks of unconsciousness that result from ventricular arrhythmias including ventricular fibrillation; autosomal dominant inheritance, with one form caused by mutation in the potassium channel gene (KVLQT1) on chromosome 11 p. Compare: Jervell and Lange-Nielsen syndrome.

Romano,

C., Italian physician, 1923–.
Romano-Ward syndrome - a prolonged Q-T interval in the electrocardiogram in children subject to ventricular arrhythmias, including ventricular fibrillation. Synonym(s): Ward-Romano syndrome
Ward-Romano syndrome - Synonym(s): Romano-Ward syndrome

Ward,

Owen C., 20th century Irish pediatrician.
Romano-Ward syndrome - see under Romano
Ward-Romano syndrome - Synonym(s): Romano-Ward syndrome
References in periodicals archive ?
Two phenotypes of Long QT Syndrome include Romano-Ward and Jervell Lange-Nielsen syndromes.
Categorization of the congenital mutations in Romano-Ward Syndrome is based on a numbering scheme with several mutations identified with types 1-3 being the most common forms seen.
Two inherited forms of LQTS with differing patterns of transmission have been described and include Romano-Ward syndrome (RWS)[5,6] and Jervell and Lange-Nielsen syndrome (JLNS).[7]
Romano-Ward syndrome is the most common inherited form of LQTS and is transmitted as an autosomal-dominant trait[1,2.5,6]; gene carriers are expected to be clinically affected (ie, they have evidence of LQTS) and have a 50% likelihood of transmitting the disease-causing gene to their offspring.
A recessive variant of the Romano-Ward long-QT syndrome.
Romano-Ward long QT syndrome (RWLQTS): evidence of genetic heterogeneity.
Evidence of genetic heterogeneity in Romano-Ward long QT syndrome: analysis of 23 families.
Properties of KVLQT1 [K.sup.+] channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias.