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Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumours. A phase III trial that assessed the efficacy and safety of tirapazamine plus cisplatin for treating non-small-cell lung cancer (NSCLC)
Conclusion The median survival was significantly longer and the response rate was significantly greater for patients who received tirapazamine plus cisplatin than for those who received cisplatin alone. Tirapazamine enhances the activity of cisplatin in patients with advanced NSCLC and confirms that hypoxia is an exploitable therapeutic target in human malignancies
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Asked about one of his latest projects, the Serpentine Gallery Pavilion, a temporary building in England that a different architect is invited to design each summer, he cites Roman catapults and Victorian garden tents as inspirations for the pavilion's big, kinetic-looking timers.
From the Roman catapults that collapsed or projected their missiles short, through the premature ignition of Greek fire and later, with the advent of artillery, the "drop-shorts," soldiers have succumbed to the well-intentioned efforts of support weapons crews.