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Related to Rivotril: clonazepam


Alti-Clonazepam (CA), Apo-Clonazepam (CA), Clonapam (CA), Co Clonazepam (CA), Dom-Clonazepam (CA), Gen-Clonazepam (CA), Klonopin, Novo-Clonazepam (CA), PHL-Clonazepam (CA), PMS-Clonazepam (CA) Ratio Clonazepam (CA), Rivotril (CA) (UK)

Pharmacologic class: Benzodiazepine

Therapeutic class: Anticonvulsant

Controlled substance schedule IV

Pregnancy risk category D


Unknown. May enhance activity of gamma-aminobutyric acid, an inhibitory neurotransmitter in CNS.


Tablets: 0.5 mg, 1 mg, 2 mg

Indications and dosages

Absence seizures (Lennox-Gastaut syndrome); akinetic and myoclonic seizures

Adults: Initially, 1.5 mg/day P.O. in three divided doses; may increase by 0.5 to 1 mg q 3 days until seizures are adequately controlled or drug intolerance occurs. Maximum dosage is 20 mg/day.

Infants and children ages 10 and younger or weighing 30 kg (66 lb) or

less: Initially, 0.01 to 0.03 mg/kg/day P.O. Give total dosage (not to exceed 0.05 mg/kg/day) in two to three equally divided doses. Increase by no more than 0.25 to 0.5 mg q 3 days until dosage of 0.1 to 0.2 mg/kg/day is reached, seizures are adequately controlled, or drug intolerance occurs.

Off-label uses

• Acute manic episodes of bipolar disorder

• Multifocal tic disorders

• Neuralgias

• Parkinsonian dysarthria

• Periodic leg movements occurring during sleep

• Adjunctive treatment of schizophrenia


• Hypersensitivity to drug or other benzodiazepines

• Severe hepatic disease

• Acute angle-closure glaucoma


Use cautiously in:

• renal impairment, chronic respiratory disease, open-angle glaucoma

• history of porphyria

• pregnant or breastfeeding patients

• children.


Be aware that overdose may cause fatal respiratory depression or cardiovascular collapse.

• Give tablets with water, and make sure patient swallows them whole.

Adverse reactions

CNS: ataxia, fatigue, drowsiness, behavioral changes, depression, dizziness, nervousness, reduced intellectual ability

CV: palpitations

EENT: abnormal eye movements, blurred vision, diplopia, nystagmus, sinusitis, rhinitis, pharyngitis

GI: constipation, diarrhea, hypersalivation

GU: dysuria, nocturia, urinary retention, dysmenorrhea, delayed ejaculation, erectile dysfunction

Hematologic: anemia, eosinophilia,

leukopenia, thrombocytopenia

Hepatic: hepatitis

Musculoskeletal: myalgia

Respiratory: increased respiratory secretions, upper respiratory tract infection, cough, bronchitis, respiratory depression

Other: appetite changes, fever, physical or psychological drug dependence, drug tolerance, allergic reaction


Drug-drug. Antidepressants, antihistamines, opioids, other benzodiazepines: additive CNS depression

Barbiturates, rifampin: increased metabolism and decreased efficacy of clonazepam

Cimetidine, disulfiram, fluoxetine, hormonal contraceptives, isoniazid, ketoconazole, metoprolol, propoxyphene, propranolol, valproic acid: decreased clonazepam metabolism

Phenytoin: decreased clonazepam blood level

Drug-diagnostic tests. Eosinophils, liver function tests: increased values

Platelets, white blood cells: decreased counts

Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

• Monitor patient for respiratory depression. Assess respiratory rate and quality, oxygen saturation (using pulse oximetry), and mental status.

• Monitor hematologic and liver function test results.

Patient teaching

Instruct patient to immediately report easy bleeding or bruising or yellowing of skin or eyes.

• Advise patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

Caution patient not to stop taking drug abruptly. Advise him to consult prescriber for dosage-tapering schedule if he wishes to discontinue drug.

• Advise patient not to drink alcohol, which may increase drowsiness, dizziness, and risk of seizures.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


(kloe-na-ze-pam) ,


(trade name),


(trade name),


(trade name)


Therapeutic: anticonvulsants
Pharmacologic: benzodiazepines
Pregnancy Category: D


Prophylaxis of:
  • Petit mal,
  • Lennox-Gastaut,
  • Akinetic,
  • Myoclonic seizures.
Panic disorder with or without agoraphobia.Uncontrolled leg movements during sleep.Neuralgias.Infantile spasms.Sedation.Adjunct management of acute mania, acute psychosis, or insomnia.


Anticonvulsant effects may be due to presynaptic inhibition.
Produces sedative effects in the CNS, probably by stimulating inhibitory GABA receptors.

Therapeutic effects

Prevention of seizures.
Decreased manifestations of panic disorder.


Absorption: Well absorbed from the GI tract.
Distribution: Probably crosses the blood-brain barrier and the placenta.
Protein Binding: 85%.
Metabolism and Excretion: Mostly metabolized by the liver.
Half-life: 18–50 hr.

Time/action profile (anticonvulsant activity)

PO20–60 min1–2 hr6–12 hr


Contraindicated in: Hypersensitivity to clonazepam or other benzodiazepines;Severe hepatic impairment.
Use Cautiously in: All patients (may ↑ risk of suicidal thoughts/behaviors);Angle-closure glaucoma;Obstructive sleep apnea;Chronic respiratory disease;History of porphyria;Do not discontinue abruptly; Obstetric: Safety not established; chronic use during pregnancy may result in withdrawal in the neonate Lactation: May enter breast milk; discontinue drug or bottle feed; Geriatric: May experience excessive sedation at usual doses; ↓ dosage recommended.

Adverse Reactions/Side Effects

Central nervous system

  • suicidal thoughts (life-threatening)
  • behavioral changes (most frequent)
  • drowsiness (most frequent)
  • fatigue
  • slurred speech
  • ataxia
  • sedation
  • abnormal eye movements
  • diplopia
  • nystagmus


  • ↑ secretions


  • palpitations


  • rash


  • constipation
  • diarrhea
  • hepatitis
  • weight gain


  • dysuria
  • nocturia
  • urinary retention


  • anemia
  • eosinophilia
  • leukopenia
  • thrombocytopenia


  • ataxia (most frequent)
  • hypotonia


  • fever
  • physical dependence
  • psychological dependence
  • tolerance


Drug-Drug interaction

Alcohol, antidepressants, antihistamines, other benzodiazepines, and opioid analgesics ; concurrent use results in ↑ CNS depression.Cimetidine, hormonal contraceptives, disulfiram, fluoxetine, isoniazid, ketoconazole, metoprolol, propranolol, or valproic acid may ↓ metabolism and ↑ toxicity of clonazepam.May ↓ efficacy of levodopa.Rifampin or barbiturates may ↑ metabolism and ↓ effectiveness.Sedative effects may be ↓ by theophylline.May ↑ serum phenytoin levels.Phenytoin may ↓ levels.Concomitant use of kava-kava, valerian, or chamomile can ↑ CNS depression.


Oral (Adults) 0.5 mg 3 times daily; may ↑ by 0.5–1 mg q 3 days. Total daily maintenance dose not to exceed 20 mg. Panic disorder—0.125 mg twice daily; ↑ after 3 days toward target dose of 1 mg/day (some patients may require up to 4 mg/day).
Oral (Children <10 yr or 30 kg) Initial daily dose 0.01–0.03 mg/kg/day (not to exceed 0.05 mg/kg/day) given in 2–3 equally divided doses; ↑ by no more than 0.25–0.5 mg q 3 days until therapeutic blood levels are reached (not to exceed 0.2 mg/kg/day).

Availability (generic available)

Tablets: 0.5 mg, 1 mg, 2 mg Cost: Generic — 0.5 mg $11.77 / 100, 1 mg $11.25 / 100, 2 mg $15.59 / 100
Orally disintegrating tablets: 0.125 mg, 0.25 mg, 0.5 mg, 1 mg, 2 mg Cost: Generic — 0.125 mg $77.93 / 60, 0.25 mg $77.93 / 60, 0.5 mg $77.80 / 60, 1 mg $88.91 / 60, 2 mg $123.19 / 60

Nursing implications

Nursing assessment

  • Observe and record intensity, duration, and location of seizure activity.
  • Assess degree and manifestations of anxiety and mental status (orientation, mood, behavior) prior to and periodically during therapy.
  • Assess need for continued treatment regularly.
  • Assess patient for drowsiness, unsteadiness, and clumsiness. These symptoms are dose related and most severe during initial therapy; may decrease in severity or disappear with continued or long-term therapy.
  • Monitor closely for notable changes in behavior that could indicate the emergence or worsening of suicidal thoughts or behavior or depression.
  • Lab Test Considerations: Patients on prolonged therapy should have CBC and liver function test results evaluated periodically. May cause an ↑ in serum bilirubin, AST, and ALT.
    • May cause ↓ thyroidal uptake of sodium iodide, 123I, and 131I.
  • Therapeutic serum concentrations are 20–80 mg/mL. Flumazenil antagonizes clonazepam toxicity or overdose (may induce seizures in patients with history of seizure disorder or who are on tricyclic antidepressants).

Potential Nursing Diagnoses

Risk for injury (Indications,  Side Effects)


  • Do not confuse clonazepam with clonidine, clozapine, clorazepate, or lorazepam. Do not confuse Klonopin with clonidine.
    • Institute seizure precautions for patients on initial therapy or undergoing dose manipulations.
  • Oral: Administer with food to minimize gastric irritation. Tablets may be crushed if patient has difficulty swallowing. Administer largest dose at bedtime to avoid daytime sedation. Taper by 0.25 mg every 3 days to decrease signs and symptoms of withdrawal. Some patients may require longer taper period (months).
    • Orally disintegrating tablets should be left in the package until use. Remove from the blister pouch. Do not push tablet through the blister; peel open the blister pack with dry hands and place tablet on tongue. Tablet will dissolve rapidly and be swallowed with saliva. No liquid is needed to take the orally disintegrating tablet.

Patient/Family Teaching

  • Instruct patient to take medication exactly as directed. Take missed doses within 1 hr or omit; do not double doses. Abrupt withdrawal of clonazepam may cause status epilepticus, tremors, nausea, vomiting, and abdominal and muscle cramps. Instruct patient to read the Medication Guide before starting and with each Rx refill, changes may occur.
  • Advise patient that clonazepam is usually prescribed for short-term use and does not cure underlying problems.
  • Advise patient to not share medication with others.
  • May cause drowsiness or dizziness. Advise patient to avoid driving or other activities requiring alertness until response to drug is known.
  • Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking any other Rx, OTC, or herbal products. Caution patient to avoid taking alcohol or other CNS depressants concurrently with this medication.
  • Advise patient to notify health care professional of medication regimen prior to treatment or surgery.
  • Instruct patient and family to notify health care professional of unusual tiredness, bleeding, sore throat, fever, clay-colored stools, yellowing of skin, or behavioral changes. Advise patient and family to notify health care professional if thoughts about suicide or dying, attempts to commit suicide; new or worse depression; new or worse anxiety; feeling very agitated or restless; panic attacks; trouble sleeping; new or worse irritability; acting aggressive; being angry or violent; acting on dangerous impulses; an extreme increase in activity and talking; other unusual changes in behavior or mood occur.
  • Advise female patients to notify health care professional if pregnancy is planned or suspected or if breast feeding. Encourage pregnant patients to enroll in North American Antiepileptic Drug (NAAED) Pregnancy Registry to collect information about safety of antiepileptic drugs during pregnancy. To enroll, patients can call 1-888-233-2334.
  • Patient on anticonvulsant therapy should carry identification at all times describing disease process and medication regimen.
  • Emphasize the importance of follow-up exams to determine effectiveness of the medication.

Evaluation/Desired Outcomes

  • Decrease or cessation of seizure activity without undue sedation. Dose adjustments may be required after several months of therapy.
  • Decrease in frequency and severity of panic attacks.
  • Relief of leg movements during sleep.
  • Decrease in pain from neuralgia.
Drug Guide, © 2015 Farlex and Partners


Clonazepam, see there.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


A brand name for CLONAZEPAM.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
I started to feel better, except for one thing: the Rivotril made me really, really sleepy.
The patient reports the presence of two psychotic episodes in his medical history, the first one occurring in 2012, with psychomotor restlessness, aggressive behaviour and delusional ideation of prejudice and persecution, for which he was admitted to "Socola" Hospital, and another similar episode occurring in March 2015, for which he was admitted to the Psychiatry Hospital of Galati and released in a partial remission state with the following treatment plan: Amisulprid, 200 mg (1-0-2), Sermion, 30 mg (0-1-0), Pramistar, 600 mg (0-1-0), Rivotril, 2 mg (0-0-1).
Vai distribuir remedio, vai distribuir remedio, se voce falar assim que vai fazer uma reuniao e falar 'oh, hoje vai ter distribuicao de Rivotril, Omeoprazol', oh, mais vai ser uma beleza" (Entrevistado GF I).
Historial de consumo: cigarrillo, alcohol, marihuana, perico, rivotril (clonazepam), extasis, pegante, acidos, hongos, heroina, bazuco.
Too poor to pay the going rate for heroin or cocaine, Tripoli's underprivileged instead turn to hard-hitting prescription pills such as Rivotril, normally used to control seizure and epilepsy, or the more popular benzhexol, a treatment for Parkinson's disease.
Al Mugahwi said clonazepam is the scientific name of a drug known as Rivotril which is used mainly for treating epilepsy patients, and as a counteractive for unrest disorders and cases of impatience.
2,27 Minimo 0 Maximo 10 Enfermedad No 69 74,2 mental Si 24 25,8 Cual Trastorno bipolar 7 31,8 enfermedad Trastorno de personalidad 4 18,2 Esquizofrenia 2 9,1 Trastorno mental 2 9,1 Otros 7 31,5 Falta ntes 73 Consumo de Si 91 97,8 sustancias No 2 2,2 psicoactivas Bazuco 15 16,5 Marihuana Bazuco 10 11 Marihuana Bazuco Pepas 5 5,5 Marihuana Solucion 5 5,5 Marihuana Bazuco Perico 4 4,4 Otros 52 57.2 Consumo Marihuana 66 71 de cada Bazuco 64 68,8 sustancia Solucion 30 32,3 psicoactiva Perico 28 30,1 Pepas 24 25,8 Coca 17 18,3 Extasis 8 8,6 Heroina 8 8,6 Acidos 6 6,5 Cacao sabanero 4 4,3 Popers 3 3,2 Rivotril 2 2,2 Hongos 2 2,2 Ketamina 1 1,1 Anfetaminas 1 1,1 Benzodiacepinas 1 1,1 Drogas 1 1,1 Cuesca 1 1,1 Frecuencia de Promedio 146 consumo de LC95% Ll 125 sustancias LC95% LS 167 por mes Des.
Antikonvulzan tedavide birinci secenek olarak fenobarbital (yukleme: 20 mg/kg IV, 10-15 dakikada, gerektiginde 5 mg/kg ek doz, en fazla 40 mg/kg; idame: 5 mg/kg/gun 12 saat arayla 2 dozda, PO), ikinci secenek olarak fenitoin (yukleme: 20 mg/kg IV, yarim saatte, gerektiginde 10 mg/kg ek doz; idame: 5 mg/kg/gun, 12 saat arayla 2 dozda, IV), ucuncu secenek olarak midazo-lam (yukleme: 0,15 mg/kg, idame: 0,01-0,06 mg/kg/saat enfuzyon) tedavileri kullanildi Midazolam enfuzyonuna ragmen nobeti kontrol altina alinamayan olgulara rivotril (0,01-0,03 mg/kg/gun en fazla 0,2 mg/kg, PO) baslandi.