Prophylactic intravenous ritodrine hydrochloride or magnesium sulphate was administered for tocolysis during postoperative care.
Despite postoperative administration of tocolytic agents, including ritodrine hydrochloride and magnesium sulphate, spontaneous labor pain occurred, resulting in extremely preterm birth at 23 weeks, 3 days of gestation.
The beta-adrenergic agent ritodrine hydrochloride is commonly used for the treatment of preterm labor in Japan.
We hypothesized that ritodrine hydrochloride would affect the preterm fetuses, thereby adversely affecting escape enzyme levels.
To examine the clinical significance of the relationship between ritodrine hydrochloride and escape enzymes in the preterm infants, we reviewed all patients who were delivered at less than 36 weeks of gestation with preterm birth in the Perinatal Center of Social Insurance Funabashi Central Hospital between July 1, 2005, and June 30, 2008.
Ritodrine hydrochloride and magnesium sulfate were administered as tocolytic agents for preterm labor and cervical insufficiency .
Patients were divided into three groups according to the use of ritodrine hydrochloride during the antepartum period, as follows: Group A, preterm infants who were not exposed to ritodrine hydrochloride in utero, Group B, preterm infants after short-term tocolysis, which means the mothers of these infants were given intravenous infusion of ritodrine hydrochloride for <1 week; Group C, preterm infants after long-term tocolysis by intravenous infusion of ritodrine hydrochloride for [greater than or equal to] 1 week.
The purpose of this study was to investigate relationships between ritodrine hydrochloride and escape enzymes in the preterm infants.
reported that administration of ritodrine hydrochloride occurred in 86% patients in Japan participating in the Multicenter Premature Labor Study Group and IV ritodrine hydrochloride was considered safe and effective for prolonging gestation in patients of preterm labor .
Although ritodrine hydrochloride is generally considered fairly safe , no reports have addressed the relationship between ritodrine hydrochloride and escape enzymes in the umbilical blood of preterm infants.
The mechanisms underlying elevated LDH levels in association with ritodrine hydrochloride are unclear; however, myocardial damage maybe due to ritodrine hydrochloride .