Ring Finger Domain

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A 40-to-60 residue zinc-finger domain macromolecular protein consensus sequence which contains a Cys3HisCys4 amino acid motif that binds two zinc cations, and mediates protein-protein interactions—e.g., with E2 enzyme. They are the specificity determinants for cellular ubiquination and associated with certain transcription factors—e.g., TIF1b, the PML-family, NFX1, XPRF
RING is an acronym for Really Interesting New Gene
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