Richter syndrome

Rich·ter syn·drome

(rik'tĕr),
a high-grade lymphoma developing during the course of chronic lymphocytic leukemia; associated with cachexia, pyrexia, dysproteinemia, and lymphomas with multinucleated tumor cells.

Richter syndrome

The development of a clinically aggressive pleomorphic large–usually B cell–lymphoma in the background of CLL–which occurs in 3-10% of CL or Waldenström's macroglobulinemia Clinical Rapid onset of intractable fever, weight loss, lymphadenopathy, hepatosplenomegaly

Rich·ter syn·drome

(rik'ter sin'drōm)
A high-grade lymphoma developing during the course of chronic lymphocytic leukemia; associated with cachexia, pyrexia, dysproteinemia, and lymphomas with multinucleated tumor cells.

Richter,

Maurice N., U.S. pathologist, 1897–.
Richter syndrome - a high-grade lymphoma developing during the course of chronic lymphocytic leukemia.
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References in periodicals archive ?
Approximately 2% to 8% of patients with CLL/SLL transform to a more aggressive B-cell lymphoma, usually diffuse large B-cell lymphoma (Richter syndrome).
Diffuse large B-cell lymphoma (Richter syndrome) in patients with chronic lymphocytic leukaemia: a cohort study of newly diagnosed patients.
Histiocytic Sarcoma: Review, Discussion of Transformation From B-Cell Lymphoma, and Differential Diagnosis
Rapid progression with transformation into an aggressive, high-grade NHL is known as Richter syndrome and may occur in up to 10% of patients with CLL [6].
The possibility of Richter syndrome with transformation of CLL into a large cell lymphoma was indeed entertained after it was later discovered that the underlying etiology of the patient's respiratory decline was due to CLL.
Chronic Lymphocytic Leukemia as an Unusual Cause of Rapid Airway Compromise
Keating, "Richter syndrome: biology, incidence, and therapeutic strategies," Cancer, vol.
Peripheral T-Cell Lymphoma of the Submandibular Salivary Gland as an Unusual Manifestation of Richter's Syndrome: A Case Report and Literature Review
De Chiara, "Richter syndrome with plasmablastic lymphoma at primary diagnosis: a case report with a review of the literature," Applied Immunohistochemistry and Molecular Morphology, vol.
Deambrogi et al., "The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation," Blood, vol.
Plasmablastic Lymphoma with Coexistence of Chronic Lymphocytic Leukemia in an Immunocompetent Patient: A Case Report and Mini-Review
Also, HD has been described to occur in patients with chronic lymphocytic leukemia, constituting a variant of Richter syndrome. Richter syndrome is defined as the development of a large cell lymphoma in patients with chronic lymphocytic leukemia, and this transformation is characterized by rapid deterioration in the patient's general condition, lymphadenopathy, and hepatosplenomegaly.
An Unusual Variant of Composite Lymphoma

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