Their paper A tetracycline-dependent ribozyme
switch allows conditional induction of gene expression in Caenorhabditis elegans is published on 30.01.2019 in the online journal Nature Communications.
rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa.
Herrin, "Unusual metal specificity and structure of the group I ribozyme
from Chlamydomonas reinhardtii 23S rRNA," FEBS Journal, vol.
Woodson, "Role of counterion condensation in folding of the Tetrahymena ribozyme
ribonuclease P, that cuts the leader 5'sequences of all tRNAs, is an example of catalytic RNA.
Joyce and others have created such ribozymes
in the laboratory and have found that RNA's propensity to form sticky base pairs with other RNA -- which is a useful property for its various cellular functions -- hampers its ability to work as a copier of other RNA molecules.
Stimulation of cellular processes for tissue-engineering applications has focused primarily on delivery of proteins or nucleic acids, antisense oligonucleotides, adenoviral-based delivery, and hammerhead ribozymes
, which have been used to modulate the expression of proteins [6, 10].
Nilesh Vaidya and Niles Lehman made a system of halved ribozymes
which could form hybrid ribozymes
combining the recognition site of one with the catalytic site of another in a Mg++ solution and found the spontaneous emergence of a single autocatalytic hybrid ribozyme
, then loops of 3, 5 and 7 collectively autocatalytic hybrid ribozymes
Crystallization of ribozymes
and small RNA motifs by a sparse matrix approach.
are poor substitutes for proteins.
These include gene regulation, related to RNA interference (RNAi), catalytic activity, belonging to the ribozymes
(RNAzymes) and in protein translation, found within ribosomal RNA (rRNA), stimulating interest in exploring the chemical basis of its activity.
, assembled downstream of a promoter, to improve the predictability of gene expression ; ribozymes
cleave the mRNA eliminating their 5' end and also act as transcription insulators.