ribozyme

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ri·bo·zyme

(rī'bō-zīm),
A nonprotein RNA biocatalyst; several cleave precursors of tRNA to yield functional tRNAs; others act on rRNA; plays a key role in intron splicing events.
Synonym(s): organic catalyst (1) , RNA enzyme
[ribonucleic acid + -zyme]

ribozyme

(rī′bə-zīm′)
n.
An RNA molecule that acts as a catalyst, especially for the cleavage of RNA strands at specific sites.

ribozyme

One of a unique class of RNA molecules that can act as cleaving enzymes in addition to storing genetic information. This is a notable exception to the general rule that all enzymes are proteins. Ribozymes form complementary base pairs in the normal manner but can cleave segments of nascent RNA during the splicing process of the formation of mature RNA transcripts of DNA. Ribozymes can be used in various ways as treatment modalities.

ribozyme

an RNA molecule with catalytic activity. Ribozymes include (a) molecules involved in processing RNA precursor molecules by cleaving PHOSPHODIESTER BONDS, for example in self-SPLICING of some precursor rRNA INTRONS; and (b) molecules catalysing key cellular reactions, for example rRNA of the large ribosomal subunit (see RIBOSOME), which is closely involved with the peptidyl transferase activity that catalyses PEPTIDE BOND formation in TRANSLATION. Ribozymes are found in EUCARYOTES, PROKARYOTES, VIRUSES and VIROIDS.
References in periodicals archive ?
Their paper A tetracycline-dependent ribozyme switch allows conditional induction of gene expression in Caenorhabditis elegans is published on 30.01.2019 in the online journal Nature Communications.
Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa.
Herrin, "Unusual metal specificity and structure of the group I ribozyme from Chlamydomonas reinhardtii 23S rRNA," FEBS Journal, vol.
Woodson, "Role of counterion condensation in folding of the Tetrahymena ribozyme II.
The ribozyme ribonuclease P, that cuts the leader 5'sequences of all tRNAs, is an example of catalytic RNA.
Joyce and others have created such ribozymes in the laboratory and have found that RNA's propensity to form sticky base pairs with other RNA -- which is a useful property for its various cellular functions -- hampers its ability to work as a copier of other RNA molecules.
Stimulation of cellular processes for tissue-engineering applications has focused primarily on delivery of proteins or nucleic acids, antisense oligonucleotides, adenoviral-based delivery, and hammerhead ribozymes, which have been used to modulate the expression of proteins [6, 10].
Nilesh Vaidya and Niles Lehman made a system of halved ribozymes which could form hybrid ribozymes combining the recognition site of one with the catalytic site of another in a Mg++ solution and found the spontaneous emergence of a single autocatalytic hybrid ribozyme, then loops of 3, 5 and 7 collectively autocatalytic hybrid ribozymes.
Crystallization of ribozymes and small RNA motifs by a sparse matrix approach.
Additionally, ribozymes are poor substitutes for proteins.
These include gene regulation, related to RNA interference (RNAi), catalytic activity, belonging to the ribozymes (RNAzymes) and in protein translation, found within ribosomal RNA (rRNA), stimulating interest in exploring the chemical basis of its activity.
used ribozymes, assembled downstream of a promoter, to improve the predictability of gene expression [125]; ribozymes cleave the mRNA eliminating their 5' end and also act as transcription insulators.