riboswitch


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riboswitch

(rī-bō-switsch),
A form of regulatory RNA sensors, with the ability to sense small molecules ranging from amino acid derivatives to vitamins. It plays a role in bacterial gene regulation.
References in periodicals archive ?
MeiraGTx entered into a research collaboration and evaluation agreement with Janssen to use their proprietary riboswitch technology to engineer regulatable gene therapy constructs encoding proprietary gene sequences from Janssen.
As part of the agreement, MeiraGTx will use their proprietary riboswitch technology to engineer regulatable gene therapy constructs encoding proprietary gene sequences from Janssen.
Recently, it has been found that the transition metals such as [Ni.sup.2+], [Co.sup.2+], and [Mn.sup.2+] have specific binding sites in RNA, in particular in the riboswitch structure [23].
The authors used SHAPE to compare the folding of the aptamer domain of the adenine riboswitch at dilute, crowded, and in vivo conditions in its free and ligand-bound state.
Ligand-induced folding of the thiM TPP riboswitch investigated by a structure-based fluorescence spectroscopic approach.
The tc-binding aptamer has been employed as synthetic riboswitch in yeast for the conditional control of gene expression [27].
Breaker, PhD, and his team of experts in microbiology and bioinformatics at Yale University's Howard Hughes Medical Institute study a type of noncoding RNA called a riboswitch that helps turn genes on and off.
This type of gene-switching sequence is known as a riboswitch because it appears on the strand of ribonucleic acid (RNA) that is first transcribed from a gene's DNA.
Under the deal, BioRelix will apply its proprietary riboswitch technology platform to identify compounds with activity against a number of bacterial targets.
Only when this chemical binds to the riboswitch does the production of CheZ proceed.
"If fluoride builds up to toxic levels in the cell, a fluoride riboswitch grabs the fluoride and then turns on genes that can overcome its effects," Breaker said.
The researchers' strategy was to modify lysine so that it would still bind to the riboswitch but the rest of the cell's biomachinery wouldn't recognize it.