Vaccinia virus-encoded ribonucleotide reductase
subunits are differentially required for replication and pathogennesis.
E2F4 and ribonucleotide reductase
mediate S-phase arrest in colon cancer cells treated with chlorophyllin.
The two components of ribonucleotide reductase
, R1 and R2, are integral to our antisense technology platform and are being used to develop very promising anticancer drugs that are currently in clinical trials," said Dr.
The modern forms of the ribonucleotide reductase
probably evolved from some- thing similar to the P.
Extensive published research on enzyme active site structures such as those found in hemerythrin, ribonucleotide reductase
, methane monooxygenase and many other enzymes reveals the presence of binuclear metallic cores, many of which are carboxylate-bridged (refs.
CALAA-01 is a combination of the RONDEL[TM] delivery system and a patented siRNA targeting the M2 subunit of ribonucleotide reductase
(RRM2), a clinically validated cancer target.
Quantitative gene expression assays for excision repair (ERCC1), thymidine phosphorylase (TYMP), stathmin (STMN1), ribonucleotide reductase
(RRM1) and other genes provide valuable information to help predict chemotherapy responses.
The patent titled "Suppression of Malignancy Utilizing Ribonucleotide Reductase
R1" protects an innovative approach to inhibiting tumor growth in mammals, including humans.
catalyzes the conversion of ribonucleotides to deoxyribonueleotides in all organisms.
Pascale's presentation was entitled 'Regulation of the Expression of the rnrB Gene Encoding the Small Subunit of Ribonucleotide Reductase
in Dictostedium Discoideum During Development'.
Bergeron reported in an earlier study that iron chelators -- molecules that tightly bind iron--prevent it from being incorporated into ribonucleotide reductase
, an iron-dependent enzyme that catalyzes a step of DNA synthesis.
catalyzes the conversion of ribonucleosides to deoxyribonucleosides and is necessary for DNA synthesis and replication.