Heterogeneous nuclear ribonucleoproteins
(hnRNPs) are complexes of RNA and protein present in the nucleus during gene transcription and subsequent post-transcriptional modification of the newly synthesised RNA (pre-mRNA).
We also know that proteins are made by a system of ribonucleoproteins
that is the physical seat of the genetic code and functions therefore as the codemaker of the cell.
Other viral protein, such as the NCP (lane 7), were not recognized by the antisera, however, a non-especific reaction was observed with the purified viral ribonucleoproteins
(lane 8), although the band was slightly larger than expected for the N-protein (34 kDa).
Differentially expressed proteins in the cerebellum were related to growth functions associated with carbohydrate metabolism [alpha-enolase (ENOA) and fructose-bisphosphate aldolase C (ALDOC)] and RNA processing [heterogeneous nuclear ribonucleoprotein
(HNR) H2 and heterogeneous nuclear ribonucleoprotein
A3 (ROA3)] (see Supplemental Material, Table S2).
The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins
We analyzed 13 different autoantigens consisting of antinuclear antigens (centromere antigen B, PmScl100, Scl70, double-stranded DNA, Sjogren syndrome antigen B, ribonucleoproteins
A and C, Sjogren syndrome antigen A proteins 52 and 60, and Sm), thyroglobulin, thyroid peroxidase, and glutamic acid decarboxylase.
Specific topics addressed include riboswitches, catalytic strategies of self-cleaving ribozymes, the synthesis of protein, the world of small nuclear ribonucleoproteins
, spliceosome structure and function, the biology of short RNAs, large noncoding RNAs in mammalian gene dosage regulation, automated in vitro selection and microarray applications for functional RNA sequences, and the prediction of RNA secondary structure.
The influenza virus NEP(NS2 protein) mediates the nuclear export of viral ribonucleoproteins
Serologic tests were positive for antinuclear antibodies (titer, 1:2560) and for antibodies to dsDNA and the ribonucleoproteins
Ro/SS-A and La/ SS-B.
Many of these signatures are found in NP, PA, and PB2 genes (viral ribonucleoproteins
[RNPs]) and are mostly located in the functional domains related to RNP-RNP interactions that are important for viral replication.
Fine specificity of the autoimmune response to the Ro/SSA and La/SSB ribonucleoproteins
Concomitantly, some HSP27 molecules are translocated into the nucleus, where they are thought to be associated with and protect ribonucleoproteins