Rh gene

Rh gene

Any of eight allelic genes that are responsible for the various Rh blood types. They have been designated as R1, R2, R0, Rz, r, r′, r″, and ry. Genes represented by small r's are responsible for the Rh-negative (Rh) blood type; those by capital R's, for the Rh-positive (Rh+) blood type.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
We would like to emphasize that comparing these observations in humans and pigs may not be appropriate, since pigs have a single RH gene, no polymorphism in the coding region of the gene has been identified and therefore, it does not appear to represent a blood group antigen for pigs [41].
[7] ABO and Rh gene and phenotypes vary widely across geographical boundaries despite the fact that the antigens involved are stable throughout the life.
ABO and Rh gene phenotypes vary widely across races and geographical boundaries despite the facts that the antigens involved are stable throughout the life.
RHD gene (BN000065) is a part of RH gene located on chromosome 1, and consisting of 10 exons and 10 introns.
ABO blood groups are determined based on a locus on chromosome 93/4the Rh gene is on the first chromosome (1).
For a meaningful grouping of these populations, homogeneity tests for ABO and Rh gene frequencies were carried out (Neel and Schull, 1954; Shami and Rasmuson, 1994).
Subsequently, for a meaningful grouping of populations and to identify uniform clusters among them, homogeneity tests were conducted for ABO and Rh gene frequencies (Neel and Schull, 1954).
has suggested link between HLA allele and Tridosha-based constitutional types.[15] Blood group antigens such as A, B, and H antigen are present on the surface of red blood cells and numerous other tissues throughout the body, which are formed by certain enzymes synthesized by ABO gene.[16] The blood group antigens remain stable throughout life even though variations in ABO and Rh genes phenotype are widely seen across races and geographical areas.[17-19]
The RH genes, namely, RHD and RHCE, are well characterized at the genetic level, with a combination of single-nucleotide polymorphisms (SNPs) in RHCE being responsible for the C/c and E/e polymorphisms; in contrast, gene deletion and hybrid RHD--RHCE genes are responsible for D-negative phenotypes, plus SNPs and hybrid genes are responsible for partial and weak D phenotypes (1, 2).
Key words: ABO and Rh genes, genetic differentiation, Haripur Hazara, Pakistani population, population genetics
Blood groups are genetically determined and the incidence of ABO and Rh genes and their phenotypes vary widely across races and geographical boundaries, despite the fact that the antigens involved are stable throughout life.