Rh antigen


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Rh antigen

Transfusion medicine Any of a composite of multiple blood group antigens on RBC membranes–eg, Rh-C–c, C, CG, Cw, Rh-D–D, weak D–formerly Du, Dw, Rh-E–e, E, Ew, Rh-G, Rh-LW, Rh-Nea and Rhnull. See Rh system.
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RH genotyping has thus been used to identify altered RH alleles and to predict whether Rh antibodies are autoantibodies or alloantibodies, and it is beginning to have an important role in improving transfusion therapy in patients with SCD by expanding the ability to provide true Rh antigen-matched RBCs for those patients with RH variant haplotypes who lack a conventional Rh antigen. This is only possible with expansion of large-scale donor molecular screening to identify donors with RH variants for genotype matching.
[13] observed a significant association between the incidence of TB and a positive Rh antigen in blood group A.
Detection level of different Rh antigens varies with different reagents and typing techniques used by the laboratories.
Harvey Klein and David Anstee had opined that the Rh antigens were present only on red cells; hence, D immunisation evolved in D negative subjects either after injection of D positive red cells or following transplacental haemorrhage from a D positive foetus.
Rh antigen emerged as second most important blood group system due to hemolytic disease of newborn and its importance in Rh (D) negative individuals in subsequent transfusions once they develop Rh antibodies6.
Demonstration of seven epitopes of the Rh antigen D using human monoclonal anti-D antibodies and red cells from D categories.
For Recording the Blood Group: Glass slides, anti-A serum& anti-B serum, Rh antigen serum, lancets, sprit swabs.
With the discovery of the Rh antigen and its relationship to hemolytic disease of the newborn in 1939 and 1940, it soon became a recognized standard of care to make every attempt to avoid transfusing Rh(D)-positive red blood cells to Rh(D)-negative individuals.[1,2] This was particularly true for Rh(D)-negative women of childbearing age.
According to the presence or absence of Rh antigens blood is classified into Rh positive or negative.
Rh antigens are coded by three pairs of allele genes on chromosome 1.
After the Rh antigens, anti-K is the most common antibody found in testing patients prior to transfusion.