reverse T3

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reverse T3

3,3',5'-Triiodothyronine, rT3 Lab medicine A conversion product of T4–thyroxine, the level of which reflects the rate of peripheral conversion of thyroid hormones of T4 to T3 Normal rT3 levels 0.15-0.77 mmol/L. See Euthryoid sick syndrome.
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Values are expressed as mean [+ or -] standard deviation, independent samples t-test was used for free triiodothyronine, free thyroxine, thyroid stimulating hormone and reverse triiodothyronine. Criteria 1: free triiodothyronine-based euthyroid sick syndrome, Criteria 2: reverse triiodothyronine-based euthyroid sick syndrome.
Association between increased levels of reverse triiodothyronine and mortality after acute myocardial infarction.
Inhibition of pituitary type 2 deiodinase by reverse triiodothyronine does not alter thyroxine-induce inhibition of thyrotropin secretion in hypothyroid rats.
From a laboratory testing perspective, this is one of the few instances when serum reverse triiodothyronine measurements are fundamental for definitive diagnosis and might be useful for ongoing patient monitoring.
Alterations of serum reverse triiodothyronine and thyroxine kinetics in chronic renal failure: role of nutritional status, chronic illness, uremia, and hemodialysis.
Effect of prednison therapy on serum levels of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3), T3-binding capacity, basal TSH level and TSH response to thyreoliberin (TRH) in children.
Total thyroxine ([T.sub.4]) Free thyroxine (F[T.sub.4]) Triiodothyronine ([T.sub.3]) Free triiodothyronine (F[T.sub.3]) [T.sub.3] resin uptake ([T.sub.3]U) or [T.sub.4]U Free thyroxine index (FTI) or T7 Thyrotropin, thyroid-stimulating hormone (TSH) Thyrotropin-releasing hormone (TRH) Reverse triiodothyronine, reverse (r[T.sub.3]) Thyroid peroxidase antibodies (TPO) TRH stimulation test Thyroglobulin Thyroglobulin antibodies
Type 3 iodothyronine deiodinase (D3) is a selenoenzyme, normally present in brain, placenta and fetal liver, and works by catalysing the conversion of thyroxine (T4) to reverse triiodothyronine (rT3) and the conversion of triiodothyronine (T3) to 3,3'-diiodothyronine, both of which are biologically inactive.
Misleadingly low free thyroxine index and usefulness of reverse triiodothyronine measurement in nonthyroidal illnesses.
Kubisova et al., "Thyroid hormone abnormalities in haemodialyzed patients: low triiodothyronine as well as high reverse triiodothyronine are associated with increased mortality," Physiological Research, vol.
Interest of reverse triiodothyronine assessment, Eur Endocrinol.

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