He would also like to develop a new reverse transcriptase inhibitor
specifically for the L1 reverse transcriptase.
Sapre, Design of novel leads: ligand based computational modeling studies on non-nucleoside reverse transcriptase inhibitors
(NNRTIs) of HIV-1, Mol.
Click Chemistry in the Synthesis of Coumarin Derivatives as Dual Action HIV-1 Protease and Reverse Transcriptase Inhibitors
. Coumarin derivatives are known to exhibit anticancer, anti-HIV, antifungal, and antibacterial activities.
Efavirenz is the non-nucleoside reverse transcriptase inhibitor
of choice with rifampicin.
Use of nucleoside reverse transcriptase inhibitors
and risk of myocardial infarction in HIV-infected patients The SMART/INSIGHT and DAD Study Groups AIDS, 2008, 22, F17-F24
Updated guidelines for the use of rifamycins for the treatment of tuberculosis among HIV-infected patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibitors
. MMWR 2004;53:37.
The group conducted a study, published recently in the New England Journal of Medicine, that investigated the association of cumulative exposure to protease inhibitors and non-nucleoside reverse transcriptase inhibitors
with the risk of myocardial infarction.
The survey, which looked at specimens from 3,130 newly diagnosed, drug-naive individuals, found that 4% of infections had mutations conferring resistance to nucleoside reverse transcriptase inhibitors
, 7% to nonnucleoside reverse transcriptase inhibitors
, and 2% to protease inhibitors.
nucleoside analogue reverse transcriptase inhibitors
(NRTIs), non-nucleoside reverse transcriptase inhibitors
(NNRTIs), RNA polymerase inhibitors, integrase inhibitors.
Zidovudine is in a class of drugs that are called nucleoside reverse transcriptase inhibitors
, which help to prevent the AIDS virus from reproducing.
But everything changed in the mid 1990s with the advent of two new classes of anti-HIV drugs--first in December 1995 with protease inhibitors, then in June 1996 with nonnucleoside reverse transcriptase inhibitors
. Researchers found that combining these new drugs with older ones in a drug cocktail improved people's health, decreased side effects, lessened the likelihood of drug resistance, and brought HIV viral loads down to undetectable levels.
These medications used in combination with other antiretrovirals, namely the nucleoside and non-nucleoside reverse transcriptase inhibitors
, truly changed HIV into a more chronic illness.