Pattern of retinoid- induced teratogenic effects: Possible relationship with relative selectivity for nuclear retinoid receptors
RARa, RARb, and RARg.
Melanocytes express some retinoid receptors
that are lost in melanoma compared to benign nevi , which could be a direct cause of vitiligo in this case.
Retinoic acid and retinoid receptors
: potential chemopreventive and therapeutic role in cervical cancer.
Granactive Retinoid is unique in that it processes innate retinoic activity, binding directly with retinoid receptors
without the need for metabolic breakdown to more biologically active forms, said the company.
EvainBrion, "The expression of nuclear retinoid receptors
in human implantation," Placenta, vol.
This superfamily also possesses steroid hormone receptors, vitamin D, retinoid receptors
and orphan receptors.
Isotretinoin is a non-selective retinoid, with actions at all retinoid receptors
, a, b and g, while adapalene has no action on a receptors.
A further indication that the receptor-binding pathway is strongly involved in retinoid dermatitis is the finding that genetically engineered mice born deficient in nuclear retinoid receptors
develop neither epidermal hyperplasia nor skin irritation after the application of topical tretinoin.
belong to a superfamily of ligand-inducible transcription factors including steroid, vitamin D, thyroid hormone, peroxisome proliferator-activated receptor, and orphan receptors with unknown functions .
Adipose tissues have long been recognized as potential sites for RA action, and where retinoid receptors
of two different subfamilies (RAR and RXR) are expressed (Haq and Chytil, 1991; Kamei et al., 1993).
Preliminary results show that cholecalciferol u pregulares vitamin D and certain retinoid receptors
, inhibits growth and invasion, induces differentiation, and decreases the expression of proteins associated with malignant transformation.
Natural retinoids are isomerized to various molecules in the skin, activating a host of retinoid receptors
. Adapalene lacks this ability and therefore activates far fewer receptors.