Restoril


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Related to Restoril: Benzodiazepines, Ativan

temazepam

Apo-Temazepam, Co Temazepam, Dom-Temazepam, Gen-Temazepam, Novo-Temazepam, Nu-Temazepam, PHL-Temazepam, PMS-Temazepam, Ratio-Temazepam, Restoril

Pharmacologic class: Benzodiazepine

Therapeutic class: Sedative-hypnotic

Controlled substance schedule IV

Pregnancy risk category X

Action

Depresses CNS at limbic, thalamic, and hypothalamic levels. Enhances effects of gamma-aminobutyric acid, resulting in sedation, hypnosis, skeletal muscle relaxation, and anticonvulsant and anxiolytic activity.

Availability

Capsules: 7.5 mg, 15 mg, 22.5 mg, 30 mg

Indications and dosages

Insomnia

Adults: 15 mg P.O. at bedtime p.r.n. Range is 7.5 to 30 mg.

Dosage adjustment

• Elderly or debilitated patients

Contraindications

• Hypersensitivity to drug or other benzodiazepines

• Pregnancy

Precautions

Use cautiously in:

• chronic pulmonary insufficiency, hepatic dysfunction, renal disease, psychoses, drug abuse

• history of suicide attempt or drug abuse

• elderly or debilitated patients

• breastfeeding patients

• children younger than age 15.

Administration

• Give at bedtime with or without food.

Adverse reactions

CNS: hangover, headache, dizziness, drowsiness, lethargy, fatigue, paradoxical stimulation, light-headedness, talkativeness, irritability, nervousness, confusion, euphoria, relaxed feeling, tremor, incoordination, impaired memory, nightmares, paresthesia

CV: chest pain, palpitations, tachycardia

EENT: eye irritation, pain, and swelling; photophobia; tinnitus

GI: nausea, vomiting, constipation, diarrhea, heartburn, abdominal pain, dry mouth, anorexia

Musculoskeletal: joint pain

Other: altered taste, body pain, physical or psychological drug dependence, drug tolerance

Interactions

Drug-drug. Antidepressants, antihistamines, opioid analgesics, other sedative-hypnotics: additive CNS depression

Digoxin: increased digoxin blood level, greater risk of toxicity

Probenecid: faster temazepam onset and prolonged effects

Theophylline: antagonism of temazepam's sedative effects

Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: additive CNS depression

Smoking: increased drug metabolism

Patient monitoring

• Monitor neurologic status carefully. Check for paradoxical reactions, especially in elderly patient.

• Watch for signs and symptoms of physical and psychological drug dependence. Stay alert for drug hoarding.

Patient teaching

• Advise patient to establish effective bedtime routine, to minimize insomnia.

• Inform patient (and significant other if appropriate) that drug may cause psychological and physical dependence and should be used only as prescribed and needed.

• Caution patient to avoid driving and other hazardous activities on day after taking drug, until he knows how it affects concentration and alertness.

• Instruct patient not to drink alcohol.

• Advise patient not to smoke or use herbs without consulting prescriber.

• Instruct patient to report suspected pregnancy.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.

Restoril

(rĕs′tə-rĭl′)
A trademark for the drug temazepam.

Restoril®

Temazepam, see there.
References in periodicals archive ?
elimination 2.6 h 3.1 h half life Active metabolites No No Impact on sleep Slight absolute Increased Stage 2, architecture increase in Reduced Stage Stage 4 (NREM) 3-4, Reduced REM Rebound insomnia No Yes Anterograde amnesia No Yes Persisting AM No +/- drowsiness (hangover) Tachyphylaxis No High (>7-10 d) Acute withdrawal No Yes (Similar to effects alcohol and phenobarbital) Drug interactions Phenothiazines Alcohol Haliperidol Oral Contraceptives SSRI's (?) Ciprofloxin Erythromicin INH Omeprazol Cimetidine Use in Pregnancy Category B Category X (Maturation defects (Teratogenic in in animal studies first trimester) at high doses Temazepam (Restoril) Usual dose 15 mg Peak effect 1.5 h Avg.
Medications in this group include: lorazepam (Ativan), clonazepam (Klonopin), triazolam (Halcion), flurazepam (Dalmane), estazolam (ProSom), and temazepam (Restoril).
The research is the first to show that eight of the most commonly used hypnotic drugs were associated with increased hazards of mortality and cancer, including the popularly prescribed medications zolpidem (known by the brand name Ambien) and temazepam (also known as Restoril), Dr.
* Benzodiazepines: Xanax, Valium, Ativan, Klonopin, Restoril, Halcion.
* anxiety meds (benzodiazepines) like Klonopin, Ativan, Xanax, and Restoril
The agency requested the labeling changes for the following medications: Ambien/Ambien CR, Butisol Sodium, Carbrital, Dalmane, Doral, Halcion, Lunesta, Placidyl, Prosom, Restoril, Rozerem, Seconal and Sonata.
The label change affects drugs including Zolpidem, marketed as Ambien/Ambien CR by Sanofi-Aventis; butabarbital, marketed as Butisol Sodium by Medpointe Pharmaceuticals HLC; flurazepam, marketed as Dalmane by Valeant Pharmaceuticals; quazepam, marketed as Doral by Questcor Pharmaceuticals; triazolam, marketed as Halcion by Pharmacia & Upjohn Inc.; eszopiclone, marketed as Lunesta by Sepracor Inc.; estazolam, marketed as Prosom by Abbott; temazepam, marketed as Restoril by Tyco Healthcare Group; ramelteon, marketed as Rozerem by Takeda Pharmaceutical Inc.; secobarbital, marketed as Seconal by Ranbaxy Pharmaceuticals Inc.; and zaleplon, marketed as Sonata by King Pharmaceuticals Inc.
"I like short-term temazepam (Restoril) for sleep, and if an anxiolytic effect is needed both day and night, I'll think about clonazepam" for short-term treatment, Dr.
A drug interaction between diphenhydramine (50 mg) and the sleeping medication temazepam (Restoril 30mg) may have led to the stillbirth of a term fetus.
Generic Trade Name Daily Dose Temazepam Restoril 15 Triazolam Halcion 0.125 Lorazepam Ativan 1 Oxazepam Serax 15 Alprazolam Xanax 0.5 Halazepam Paxipam(*) 20 Benadryl/Atarax/Vistaril 25 * Not indicated for sleep and incorrectly listed as SABZ
In fourth operation, ANF Lahore arrested two accused namely Javed alias Bau and Mohammad Shahzad residents of Multan at Faisalabad International Airport and recovered 670 Restoril Capsules weighing 170 Grams which was kept in bottom of the brief case.
Temazepam (Restoril) should not be taken by pregnant women of by women who may become pregnant because of an association with an increased risk of birth defects.