Also found in: Dictionary.
Related to Requip: Restless Leg Syndrome, Requip XL


(roe-pin-i-role) ,


(trade name),

Requip XL

(trade name)


Therapeutic: antiparkinson agents
Pharmacologic: dopamine agonists
Pregnancy Category: C


Management of signs and symptoms of idiopathic Parkinson’s disease.Restless leg syndrome (immediate-release only).


Stimulates dopamine receptors in the brain.

Therapeutic effects

Decreased tremor and rigidity in Parkinson’s disease.
Decreased leg restlessness.


Absorption: 55% absorbed following oral administration.
Distribution: Widely distributed.
Metabolism and Excretion: Extensively metabolized by the liver (by cytochrome P450 CYP1A2 enzyme system); <10% excreted unchanged in urine.
Half-life: 6 hr.

Time/action profile

POunknownunknown8 hr


Contraindicated in: Hypersensitivity.
Use Cautiously in: Hepatic impairment (slower titration may be required);Severe cardiovascular disease; Obstetric / Lactation / Pediatric: Safety not established; may inhibit lactation; Geriatric: ↑ risk of hallucinations.

Adverse Reactions/Side Effects

Central nervous system

  • sleep attacks (life-threatening)
  • dizziness (most frequent)
  • syncope (most frequent)
  • confusion
  • drowsiness
  • fatigue
  • hallucinations
  • headache
  • dyskinesia
  • impulse control disorders (gambling, sexual)
  • weakness

Ear, Eye, Nose, Throat

  • abnormal vision


  • orthostatic hypotension
  • peripheral edema


  • constipation
  • dry mouth
  • dyspepsia
  • nausea
  • vomiting


  • sweating
  • melanoma


Drug-Drug interaction

Drugs that alter the activity of cytochrome P450 CYP1A2 enzyme system may affect the activity of ropinirole.Effects may be ↑ by estrogens.Effects may be ↓ by phenothiazines, butyrophenones, thioxanthenes, or metoclopramide.May ↑ effects of levodopa (may allow dose ↓ of levodopa).


Oral (Adults) Parkinson's disease—Immediate-release: 0.25 mg 3 times daily for 1 wk, then 0.5 mg 3 times daily for 1 wk, then 0.75 mg 3 times daily for 1 wk, then 1 mg 3 times daily for 1 wk; then may ↑ by 1.5 mg/day every wk up to 9 mg/day; then may ↑ by up to 3 mg/day every wk up to 24 mg/day; Extended-release: 2 mg once daily for 1–2 wk; may ↑ by 2 mg/day every wk up to 24 mg/day. Restless leg syndrome—0.25 mg once daily initially, 1–3 hr before bedtime. After 2 days, ↑ to 0.5 mg once daily and to 1 mg once daily by the end of first week of dosing, then ↑ by 0.5 mg weekly, up to 4 mg/day as needed/tolerated.

Availability (generic available)

Tablets: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg, 5 mg Cost: Generic — 0.25 mg $250.21 / 100, 0.5 mg $250.21 / 100, 1 mg $250.21 / 100, 2 mg $250.21 / 100, 3 mg $259.54 / 100, 4 mg $259.85 / 100, 5 mg $259.85 / 100
Extended-release tablets: 2 mg, 4 mg, 6 mg, 8 mg, 12 mg Cost: Generic — 2 mg $82.05 / 30, 4 mg $164.10 / 30, 6 mg $246.16 / 30, 8 mg $246.16 / 30, 12 mg $410.47 / 30

Nursing implications

Nursing assessment

  • Assess BP periodically during therapy.
  • Assess patient for drowsiness and sleep attacks. Drowsiness is a common side effect of ropinirole, but sleep attacks or episodes of falling asleep during activities that require active participation may occur without warning. Assess patient for concomitant medications that have sedating effects or may increase serum ropinirole levels (see Interactions). May require discontinuation of therapy.
  • Parkinson's Disease: Assess patient for signs and symptoms of Parkinson’s disease (tremor, muscle weakness and rigidity, ataxic gait) prior to and during therapy.
  • Restless Leg Syndrome: Assess sleep patterns and frequency of restless leg disturbances.
  • Lab Test Considerations: May cause ↑ BUN.

Potential Nursing Diagnoses

Impaired physical mobility (Indications)
Risk for injury (Indications,  Side Effects)


  • Do not confuse ropinirole with Risperdal (risperidone) or risperidone.
  • Oral: May be administered with or without food. Administration with food may decrease nausea. Extended-release tablets should be swallowed whole; do not break, crush, or chew.

Patient/Family Teaching

  • Instruct patient to take medication exactly as directed. Missed doses should be taken as soon as possible, but not if almost time for next dose. Do not double doses.
  • Caution patient to change positions slowly to minimize orthostatic hypotension.
  • May cause drowsiness and unexpected episodes of falling asleep. Caution patient to avoid driving or other activities requiring alertness until response to medication is known. Advise patient to notify health care professional if episodes of falling asleep occur.
  • Advise patient to avoid alcohol and other CNS depressants concurrently with ropinirole.
  • Advise patient that increasing fluids, sugarless gum or candy, ice, or saliva substitutes may help minimize dry mouth. Consult health care professional if dry mouth continues for >2 wk.
  • Advise patient to have periodic skin exams to check for lesions that may be melanoma.
  • Advise patient to notify health care professional if new or increased gambling, sexual, or other impulse control disorders occur.

Evaluation/Desired Outcomes

  • Decreased tremor and rigidity in Parkinson’s disease.
  • Decrease in restless legs and improved sleep.


A trademark for the drug ropinirole hydrochloride.


Ropinirole Pharmacology A 2nd-generation dopamine agonist for treating Parkinson's disease. See Parkinson's disease.


A brand name for ROPINIROLE.
References in periodicals archive ?
He was similarly started on both Requip and Mirapex and failed both of them in similar fashion to his son but was also treated with home CPAP for his obstructive sleep apnea.
ReQuip is taken to alleviate the symptoms of the central nervous system disorder, which causes shaking.
While taking Requip, Jambart attempted suicide eight times and his risky sexual encounters resulted in him being raped.
Sadly, there is no alternative to ReQuip but Vicki was referred to counselling to help her control her urges.
At that point he told his doctor about his gambling problem, stopped taking Requip and has not been back to Vegas.
The approval is for multiple strengths of the drug, which is the generic version of GlaxoSmithKline Plc's Requip that is used to treat Parkinson's disease and primary restless leg syndrome.
Patients should 22 mg also tell their doctor 24 mg if they experience new or increased gambling, sexual, or other intense urges while taking Requip XL.
Ropinirole, a non-ergoline dopamine agonist, is marketed as Requip by Glaxo-SmithKline Inc.
The most common drugs in this category used for sleep, specifically movement disorders, include Sinemet (levodopa/carbidopa), dopamine agonists such as Requip (ropinirole), and Mirapex (pramipexole) both FDA approved for restless legs in recent years.
In the regional portfolio, ahead of final year results due to be announced on Thursday, GlaxoSmithKline's drug Requip XL was again in the spotlight.
is a dopamine agonist that was first approved by the FDA for the treatment of Parkinson's disease in 1997, along with GlaxoSmithKline's similar drug Requip (ropinirole).