reperfusion injury


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re·per·fu·sion in·ju·ry

myocardial impairment, usually with arrhythmia, following the opening of arterial blockage and considered to be due to oxygen-derived free radicals.
Cardiology Myocardial injury caused by rapid flow of blood into areas previously rendered ischaemic by coronary artery occlusion. Reperfusion injury is attributed to oxidative stress, which may cause arrhythmia, infarction, myocardial stunning
Traumatology A component of crush syndrome, which occurs when blood flow is re-established to an organ or tissue exposed to prolonged ischaemia; renewed blood flow aggravates tissue damage either by causing additional injury or by unmasking injury sustained during the ischaemic period. Reperfusion injury occurs in the heart, intestine, kidney, lung, and muscle, and is due to microvascular damage

reperfusion injury

Cardiology Myocardial injury caused by rapid flow of blood into areas previously rendered ischemic by coronary artery occlusion; RI is attributed to oxidative stress, which may cause arrhythmia, infarction, myocardial stunning. See Reperfusion Traumatology A component of crush syndrome, which occurs when blood flow is reestablished to an organ or tissue exposed to prolonged ischemia; renewed blood flow aggravates tissue damage either by causing additional injury or by unmasking injury sustained during the ischemic period; RI occurs in the heart, intestine, kidney, lung, and muscle, and is due to microvascular damage. See Calcium paradox, Oxygen paradox.

reperfusion injury

The damage, and loss of function, that commonly occurs in the heart muscle when, after a heart attack, the flow of blood to the muscle is restored. Reperfusion injury is generally agreed to be due mainly to the action of oxygen FREE RADICALS. It is also known as myocardial stunning.
References in periodicals archive ?
Effect of different concentrations of inactivated lactobacillus (ILA) after ischemia reperfusion injury (IRI) on the protein levels of TLR4, A20, and I-[kappa]B assayed by western blot analysis (n=4).
Zhu et al., "Hyperglycemia and liver ischemia reperfusion injury: a role for the advanced glycation endproduct and its receptor pathway," American Journal of Transplantation, vol.
(10.) Rosero-Salazar DH (2016) Image analysis of oxidative and glycolytic muscle fibers during reperfusion injury by segmentation based on regions.
Datta, "Molecular mechanisms of liver ischemia reperfusion injury: insights from transgenic knockout models," World Journal of Gastroenterology, vol.
Daly, "Beneficial Effect of Enteral Glycine in Intestinal Ischemia/ Reperfusion Injury," Journal of Gastrointestinal Surgery, vol.
Our data showed that HDGF induced PKC[epsilon] phosphorylation (Figure 4(c)).Phosphorylated PKC[epsilon] has been shown to translocate into mitochondria and interacts with ALDH2 contributing to 4-HNE detoxification during reperfusion injury [24].
Farrell, "Hepatic ischemia reperfusion injury: pathogenic mechanisms and basis for hepatoprotection," Journal of Gastroenterology and Hepatology, vol.
Oxidative stress and apoptosis have been identified to play important roles in the process of myocardial reperfusion injury [4, 5].
Key words: Acute kidney injury; Anesthesia, general; Anesthetics, inhalation; Sevoflurane; Ischemia; Reperfusion injury
Conclusions: Reperfusion injury was not primarily related to apoptosis and it was a slowly progressive benign event in patients with ST-segment elevation myocardial infarction-acute coronary syndrome.

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