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Pregnancy Category: C
Pharmacologic: phosphate binders
ClassificationTherapeutic: electrolyte modifiers
Pharmacologic: phosphate binders
Reduction of serum phosphate levels in patients with hyperphosphatemia associated with end-stage renal disease.
A polymer that binds phosphate in the GI tract, preventing its absorption.
Decreased serum phosphate levels and reduction in the consequences of hyperphosphatemia (ectopic calcification, secondary hyperparathyroidism with osteitis fibrosa).
Absorption: Not absorbed; action is local (in GI tract).
Metabolism and Excretion: Eliminated in feces.
Time/action profile (↓ in serum phosphate levels)
|PO||5 days||2 wk||unknown|
Contraindicated in: Hypersensitivity;Hypophosphatemia;Bowel obstruction.
Use Cautiously in: Dysphagia, swallowing disorders, severe GI motility disorders, or major GI tract surgery; Obstetric / Lactation / Pediatric: Safety not established.
Adverse Reactions/Side Effects
- bowel obstruction/perforation (life-threatening)
- esophageal obstruction (tablet) (life-threatening)
- diarrhea (most frequent)
- dyspepsia (most frequent)
- vomiting (most frequent)
- choking (tablet)
- dysphagia (tablet)
Drug-Drug interactionMay ↓ absorption of other drugs and ↓ effectiveness, especially drugs whose efficacy is dependent on tightly controlled blood levels.↓ absorption of ciprofloxacin.
Oral (Adults) 800–1600 mg with each meal; may titrate by 800 mg every 2 wk to achieve target serum phosphorus levels.
Tablets: 400 mg, 800 mg
Powder for oral suspension: 800 mg/packet, 2400 mg/packet
- Assess patient for GI side effects periodically during therapy.
- Lab Test Considerations: Monitor serum phosphorous, calcium, bicarbonate, and chloride levels periodically during therapy.
Potential Nursing DiagnosesDeficient knowledge, related to medication regimen (Patient/Family Teaching)
- Do not confuse Renagel with Renvela.
- Doses of concurrent medications, especially antiarrhythmics, should be spaced at least 1 hr before or 3 hr after sevelamer.
- Oral: Administer with meals. Do not break, chew, or crush tablets; contents expand in water.
- Place contents of powder packet in a cup and mix thoroughly with at least 1 ounce of water for the 0.8-g dose or 2 ounces of water for the 2.4-g dose packet. Stir mixture vigorously (it does not dissolve) and drink entire preparation within 30 min or resuspend the preparation right before drinking.
- Instruct patient to take sevelamer with meals as directed and to adhere to prescribed diet.
- Caution patient to space concurrent medications at least 1 hr before or 3 hr after sevelamer.
- Advise patient to notify health care professional if GI effects are severe or prolonged.
- Decrease in serum phosphorous concentration to ≤6 mg/dL. Dose adjustment is based on serum phosphorous concentrations.
Drug Guide, © 2015 Farlex and Partners
sevelamerA phosphate chelator used to reduce phosphorus in patients with end-stage renal disease and in chronic renal failure patients not requiring dialysis. It also reduces uric acid levels, and may be of use in patients with hyperuricaemia, uric acid nephrolithiasis and gout.
Blood pressure lability (hypo- or hypertension), nausea, vomiting, dyspepsia, diarrhoea, constipation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Renagel®Sevelamer, see there.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.