Remeron


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mirtazapine

Apo-Mirtazapine (CA), Dom-Mirtazapine (CA), Gen-Mirtazapine (CA), Novo-Mirtazapine (CA), PHL-Mirtazapine (CA), PMS-Mirtazapine (CA), Ratio-Mirtazapine (CA), Remeron, Remeron RD (CA), Remeron Soltab, Riva-Mirtazapine (CA), Sandoz Mirtazapine (CA), Zispin (UK)

Pharmacologic class: Piperazinoazepine derivative

Therapeutic class: Tetracyclic antidepressant

Pregnancy risk category C

FDA Box Warning

• Drug may increase risk of suicidal thinking and behavior in children and adolescents with major depressive disorder and other psychiatric disorders. Risk must be balanced with clinical need, as depression itself increases suicide risk. With patient of any age, observe closely for clinical worsening, suicidality, and unusual behavior changes when therapy begins. Advise family and caregivers to observe patient closely and communicate with prescriber as needed.

• Drug isn't approved for use in pediatric patients.

Action

Potentiates effects of norepinephrine and serotonin by blocking their synaptic reuptake. Also exerts anticholinergic activity by disrupting muscarinic receptors.

Availability

Tablets: 15 mg, 30 mg, 45 mg

Tablets (orally disintegrating): 15 mg, 30 mg, 45 mg

Indications and dosages

Depression

Adults: Initially, 15 mg/day as a single dose at bedtime; may increase dosage q 1 to 2 weeks up to 45 mg/day. For maintenance, 15 to 45 mg/day.

Dosage adjustment

• Renal or hepatic impairment

• Elderly patients

Contraindications

• Hypersensitivity to drug

• MAO inhibitor use within past 14 days

Precautions

Use cautiously in:

• hepatic or renal impairment

• history of seizures, cardiovascular or cerebrovascular disease, or psychiatric illness

• elderly patients

• pregnant or breastfeeding patients

• children (safety not established).

Administration

• Administer orally disintegrating tablet without water. Have patient place it on tongue until it melts. Make sure tablet isn't broken.

• Be aware that drug is usually used in conjunction with psychotherapy.

Don't give within 14 days of MAO inhibitors.

Adverse reactions

CNS: drowsiness, dizziness, abnormal dreams, abnormal thinking, asthenia, tremor, confusion, suicidal behavior or ideation (especially in child or adolescent)

CV: orthostatic hypotension, chest pain

EENT: sinusitis

GI: constipation, dry mouth

GU: urinary frequency, urinary tract infection

Hematologic: agranulocytosis

Musculoskeletal: back pain, myalgia

Respiratory: increased cough, dyspnea

Skin: photosensitivity

Other: flulike symptoms, edema, increased appetite, weight gain, increased thirst

Interactions

Drug-drug. Benzodiazepines, other CNS depressants: additive CNS depression

Drugs metabolized by CYP450 enzyme: altered metabolism of these drugs

MAO inhibitors: hypertension, seizures, death

Drug-diagnostic tests. Alanine aminotransferase, cholesterol, triglycerides: increased levels

Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression

S-adenosylmethionine (SAM-e), St. John's wort: increased risk of serotonergic adverse effects (including serotonin syndrome)

Drug-behaviors. Alcohol use: additive CNS effects

Patient monitoring

• Monitor vital signs, especially for orthostatic hypotension.

• Assess neurologic status.

• Watch for weight gain caused by edema or increased appetite.

• Stay alert for urinary tract infection, sinusitis, and flulike symptoms.

Monitor CBC with white cell differential. Stay alert for agranulocytosis.

Watch for suicidal behavior or ideation (especially in child or adolescent).

Patient teaching

• Advise patient to take with food or milk to reduce GI upset.

• Tell patient he may crush conventional tablets if he can't swallow them whole.

• Instruct patient to take orally disintegrating tablet without water. Tell him to place it on tongue until it melts and to make sure tablet isn't broken.

• Advise patient that therapeutic effects may take 2 to 3 weeks.

Tell patient to immediately report sore throat, fever, mouth sores, or other signs or symptoms of infection.

Instruct patient (or parent) to immediately report suicidal thoughts or actions (especially in child or adolescent).

Caution patient not to discontinue drug abruptly. Dosage must be tapered.

• If drug causes oversedation, tell patient to consult prescriber about taking entire daily dose at bedtime.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Tell patient to avoid alcohol and to discuss herbal use with prescriber.

• Instruct patient to avoid exposure to excessive sunlight or sun lamps.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

Remeron

(rĕm′ə-rŏn)
A trademark for the drug mirtazapine.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

mirtazapine

A psychoactive agent of the benzazepine and tetracyclic antidepressant (TeCA) chemical classes, which is used primarily for moderate to severe clinical depression, but also as an anxiolytic, hypnotic, antiemetic, orexigenic, antihistaminic or antipruritic.

Adverse effects
Dizziness, blurred vision, sedation, drowsiness, malaise or lassitude, hyperphagia and subsequent weight gain.
 
Rare (1:1000 patients) adverse effects
Allergic reaction, oedema, syncope, seizures, myelotoxicity, myelodysplasia, agranulocytosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Remeron®

Mirtazipine, see there.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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Tanton identifies some 374 different mental conditions that were given definition to justify the use of Prozac, Paxil, Zoloft, Celexa, Wellbutrin, Zyban, Remeron, Serzone, Effexor, Buspar, Risperdal, Zyprexa, Seroquel, Geodon, Depakote, and Adderall.
Atypical antidepressants, such as venlafaxine (Effexor) and mirtazapine (Remeron), may also help by enabling certain brain chemicals such as serotonin, norepinephrine and dopamine to remain in the brain longer.
Khankari contributed to the development and launch of partner products such as Wyeth's Alavert, AstraZeneca's Zomig ZMT, Organon's Remeron Soltabs Novartis' Triaminic Softchews, and the newest Cephalon product, FENTORA (fentanyl buccal tablet) [C-II], for cancer patients with breakthrough pain.
The list of drugs obtained from this search was reviewed by a leading academic mental health expert, and a final list of the following 13 drugs was selected: antipsychotics--risperidone (Risperdal), olanzapine (Zyprexa), and quetiapine (Seroquel)--and anti-depressants--citalopram (Celexa), fluoxetine (Prozac), paroxetine (Paxil), fluvoxamine (Luvox), sertraline (Zoloft), venlafaxine (Effexor), nefazodone (Serzone), trazodone (Desyrel), mirtazapine (Remeron), and bupropion (Wellbutrin).