transplant rejection

(redirected from Rejection reaction)

transplant rejection

Graft rejection, organ rejection, tissue rejection Immunology The constellation of host immune responses evoked when an allograft tissue is transplanted into a recipient; rejection phenomena may be minimized by optimal matching of MHC antigens and ABO blood groups and ameliorated with immunosuppressants–eg, cyclosporin, tacrolimus, rapamycin Exceptions of TR Corneal transplants, identical twins. See Graft-versus-host disease, HLA, MHC, Tissue typing.
References in periodicals archive ?
All these devices require a reliable method to protect the implanted parts from corrosion caused by body fluids and the patient from the rejection reaction caused by an "alien" object in the body.
HLA are the group of tissue antigens, controlled by the chromosomal region, bearing a number of genetic loci, each with multi alleles, that have relevance to transplantation rejection reaction & other immunological phenomena [1, 2].
For example, giving group B blood to someone with group O would have a massive rejection reaction. But there's good news for those with blood group AB positive, known as the 'universal recipient' type, because they can accept blood from any group.
Dental pulp stem cells has relatively low immunogenicity with rare rejection reaction, thus it can be used for oneself and their immediate family members, which ultimately bring health to families.
Patients did not experience any rejection reaction or require long-term immune suppression, which are serious side effects associated with the use of human donor tissue.
The allospecific rejection reaction occurred at the contact site between the growing edges of incompatible colonies.
In a study involving nearly 4,000 patients published last year in the Journal of the American Society of Nephrology, Professor Gerhard Opelz, Caner Suesal, MD, and colleagues of the Heidelberg University Hospital found that the higher the soluble CD30 level, the more likely a rejection reaction.
Gray was the first coach of the modern era to suffer the ultimate Welsh Rugby Union rejection reaction - a mere three months after a side including the likes of Jonathan Davies, Robert Jones, Robert Norster and Paul Thorburn took Wales to their first - and last - Triple Crown since 1979.
During a rejection reaction between two colonies, classic cytotoxic responses are visible under the light microscope (e.g., Scofield and Nagashima 1983).
The Food and Drug Administration has approved these various forms of cortisone as safe and effective -- when used appropriately -- for treating Addison's disease; for symptomatic relief of inflammation due to a variety of causes, such as rheumatic fever and tuberculosis, for immunosuppression (helping control the rejection reaction accompanying organ transplants); for cancer therapy (especially lymphocitic leukemia, Hodgkin's disease, and breast cancer); and for a variety of other ailments, such as bronchial asthma and hypercalcemia (excessive calcium in the blood).
Colony specificity is a type of self-nonself recognition and rejection reaction against conspecifics that occurs in many colonial forms of animals; allogeneic colonies fuse to form a single mass or reject each other when the colonies come into contact at their growing edges, whereas syngeneic colonies always fuse with each other.