After intravenous injection, PNT2258 achieves systemic distribution, delivering PNT100 into the nuclei of cancer cells where it is designed to target and interfere with the regulatory region
of the BCL2 oncogene.
DNA methylation levels of two of three CpG sites from the PPARG1 gene regulatory region
(+144 to +225) were lower (p<0.
The protein Chrono binds to the regulatory region
of clock genes, with its repressor function oscillating in a circadian manner.
2 kb of the regulatory region
upstream of the human ACHE gene, we evaluated TCDD's effects on the promoter activity of human AChE.
Association of the serotonin transporter promoter regulatory region
polymorphism and obsessive-compulsive disorder.
The regulatory region
of the human OXTR gene displays binding sites for several transcription factors, such as growth associated binding protein, CCAAT/enhancer-binding protein (C/EBP), activator protein-1 (AP-1), Sp-1, nuclear factor-icB (NK-kB), and NF-interleukin-6 (Kimura et al.
Because deletions in the viral genome have been reported in the VP2 sequence and the regulatory region
of hamster polyomavirus (11), a virus that causes lymphomas, the sequence encompassing part of the VP2 protein and the regulatory region
(4,876-238) of 7 MCPyV isolates were PCR amplified with the primer set RegF/RegR (5'-TGTTCAGCTGTGAACCCAAG-3' and 5'-GAGC CTCTCTTTCTTTCCTATTT-3', respectively), cloned, and sequenced.
The BKV regulatory region
, which is located between the DNA replication origin and the agnoprotein gene, has many important functions: transcriptional regulation of the early and late coding regions, control of viral replication by means of promoter-enhancer sequences, and the regulation of host cell oncogenes (c-myc) and tumor suppressor genes (p53 and pRb).
The first genetic construct comprises a first regulatory region
operatively linked to a gene of interest and at least one repressor sequence capable of controlling the activity of the first regulatory region
A 222-bp PCR product is generated from the regulatory region
of the lactase gene and analyzed by melting curve analysis.
Investigators found that in the transcriptional regulatory region
of the SDC2 gene, tumor samples showed significantly higher levels of methylation than the control samples.
Previous findings indicate that the regulatory region
of PERV for retroviral transcription, replication and integration into the cellular DNA is located on the 5' Long Terminal Repeat (LTR).