TAAAG###TAAAGSTKST1###2###3###2###2###5###Guard cell specific regulatory element
(Plesch et al., 2001).
A better understanding of the genome's regulatory elements
could shed light on the genetic basis of diseases, and the data from the ENCODE project will be critical to answering those types of questions, Mr.
Researchers might use the technique to find regulatory elements
that could make a chicken look like a dinosaur or an elephant look like a mammoth, he says.
The Regulatory Element
program focuses on compliance, regulatory, ethical and sales-practice standards.
Currently available data suggest that regulatory elements
controlling gene expression constitute as much as 10%-20% of our genome, dwarfing the 1%-2% of genomic real estate devoted to protein-coding genes.
The new study is one of the first to show how such regions, called regulatory elements
, can influence people's risk of disease.
Absence of expression of the FMR1 gene is caused by a mutation in the regulatory elements
that govern its expression.
They showed that the substance 5-azaC was able to clear the methyl groups from the regulatory elements
of the gene, allowing for the efficient restoration of FMR1 expression in both stem and neuronal brain cells.
The scientists have shown that chromosomes fold in a series of contiguous "yarns" that harbor groups of genes and regulatory elements
, bringing them in contact with each other and allowing them to work in a coordinated manner during development.
Scientists have devised a new computational model that can be used to reveal genetic regulatory elements
responsible for development of the human heart and maintenance of its function.
The identification of the repertoire of regulatory elements
in a genome is one of the major challenges in modern biology and also important for the study of gene expression and its regulatory machinery.