RNA interference

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RNA interference

n. Abbr. RNAi
A process in which double-stranded RNA inhibits the expression of genes by triggering degradation of messenger RNAs with complementary sequences.

RNA interference

,

RNAi

The blocking of gene expression by disrupting the translation of messenger RNA into proteins. Synonym: posttranscriptional gene silencing
References in periodicals archive ?
Pollard and her colleagues speculate that this region produces a regulatory RNA and that changes in this RNA contributed to the evolution of the human brain.
Now it's clear that a single length of DNA can be transcribed in multiple ways to produce many different RNAs, some coding for proteins and others constituting regulatory RNAs. By starting and stopping in different places, the transcription machinery can generate a regulatory RNA from a length of DNA that overlaps a protein-coding gene.
Scientists at the Ovarian Cancer Institute Laboratory at the Georgia Institute of Technology have found in initial tests that a regulatory RNA called miR-429 may be successful in inducing metastatic or spreading cancer cells to convert back to a less metastatic, non-invasive form.
"With the Magna Nuclear RIP kits, researchers now have complete, user-friendly kits to facilitate isolation and identification of regulatory RNAs such as short and long non-coding RNAs, snRNAs and enhancer RNAs."
Oncologists, geneticists, and biochemists from the US and Europe explore such aspects of the current field as the regulation of ion channel and transporter function through RNA editing, the coordination of RNA editing with RNA processes in kinotoplastic mitochondria, RNA editing and small regulatory RNAs, deaminase-dependent and deaminase-independent functions of APOBEC1 and its complementation factor in the context of the APOBEC family, and ADAR and the balance game between virus infection and innate immune cell response.
Endogenous small regulatory RNAs are of intense research interest because they act as cellular rheostats, subtly modulating gene expression.
Like many other non-coding RNAs, small regulatory RNAs (sRNA) in bacteria interact with other RNAs and proteins in order to regulate bacterial lifestyle.
Although we know a lot about the mechanisms of action of ncRNAs, and their role in the context of viral infections, we know much less regarding the control of the regulatory RNAs themselves.
MicroRNAs are native small regulatory RNAs of about 22 nucleotides in eukaryotes, evolutionarily conserved molecules that can repress translation or degrade the RNA transcripts of target genes, depending on the degree of complementarity.

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