The investigation of product issues also sees a boost from this new capability, as detailed comparison between good and problem samples will reveal issues such as non-optimal TAG composition or rearrangement to a different regioisomer
Each regioisomer can form 8 racemic diastereomers leading to 64 theoretically possible different [F.
The regioisomers differ by the length of the alkyl side chains and/or by the position of the 3rd hydroxyl group on the side chain and can, therefore, be distinguished by monitoring typical daughter ions generated in MRM mode.
Two-dimensional database of mouse liver proteins: changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer
The regioisomer identity of docosahexaenoate preparations could not be confirmed because of a lack of commercial calibrators.
In the case of linoleic acid, the major PUFA in biological systems, this produces two possible FAOOH and two possible FAOH regioisomers (i.
From that, the scientists can develop ratios of regioisomers
that can be used to determine whether the sample contains any oil other than that extracted from olives.
Based on a recent clinical study showing an interaction between a silymarin product and the CYP2C9 substrate losartan, the CYP2C9 inhibition properties of silybin A and silybin B and corresponding regioisomers
, isosilybin A and isosilybin B, were evaluated using human liver microsomes (HLMs), recombinant CYP2C9 (rCYP2C9) enzymes, and the clinically relevant probe, (S)-warfarin.
Synthesis of the isoxazole and isoxazoline subunits present in these drug leads requires the [3+2] cycloaddition which forms a mixture of regioisomers
in traditional organic solvents.
The applied hydroboration procedure leads to a chromatographically inseparable mixture of hydroxylated diasereo- and regioisomers
4a and 4b, in a ratio of 3 : 1 (determined by NMR).
Distinct kinetic properties of the 3 regioisomers
, observed with lamb intestinal lactase in vitro (19), suggested that they could behave differently in vivo.
2] the ratio of regioisomers
was only 3 : 1 (47% of [gamma]-oxygenation versus 15% of [alpha]-oxygenation) (Table 1, No.