Reed-Sternberg cell

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Reed-Stern·berg cell

(rēd shtĕrn'bĕrg),

large transformed lymphocytes, probably B cell in origin, generally regarded as pathognomonic of Hodgkin disease; a typical cell has a pale-staining acidophilic cytoplasm and one or two large nuclei showing marginal clumping of chromatin and unusually conspicuous deeply acidophilic nucleoli; binucleate Reed-Sternberg cell frequently shows a mirror-image form (mirror-image cell).

Synonym(s): Reed cell, Sternberg cell, Sternberg-Reed cell

Reed-Sternberg cell

(rēd′stûrn′bûrg′)

A large, abnormal, binucleated or multinucleated B cell that is characteristic of Hodgkin lymphoma.

Reed-Sternberg cell

Etymology: Dorothy M. Reed, American pathologist, 1874-1964; Karl Sternberg, Austrian pathologist, 1872-1935

one of a number of large, abnormal, multinucleated reticuloendothelial cells in the lymphatic system found in Hodgkin's disease. The number and proportion of Reed-Sternberg cells identified are the basis for the histopathological classification of Hodgkin's disease.

Reed-Sternberg cell

Reed-Stern·berg cell

(rēd-stĕrn'bĕrg sel)

Large transformed lymphocytes, probably B cell in origin, generally regarded as pathognomonic of Hodgkin lymphoma; a typical cell has a pale-staining acidophilic cytoplasm and one or two large nuclei showing marginal clumping of chromatin and unusually conspicuous deeply acidophilic nucleoli; binucleate Reed-Sternberg cells frequently show a mirror-image form (mirror-image cell).

REED-STERNBERG CELL: Reed-Sternberg cell in Hodgkin Lymphoma

Reed-Sternberg cell

(rēd′stĕrn′bĕrg″)

[Dorothy Reed, U.S. pathologist, 1874–1964; Karl Sternberg, Aust. pathologist, 1872–1935]

A giant, malignant, multinucleated B lymphocyte, the presence of which is the pathologic hallmark of Hodgkin's disease.

See: illustration

Reed-Sternberg cell

A giant cell with paired, mirror-image nuclei that is a diagnostic feature of HODGKIN'S LYMPHOMA and distinguishes it from non-Hodgkin's lymphoma. (Dorothy M. Reed, 1874–1964, American pathologist; and Karl von Sternberg, 1872–1935, Austrian pathologist).

Reed-Sternberg cell

see Reed-Sternberg cell.

References in periodicals archive ?

Hodgkin's lymphoma in Indian children: prevalence and significance of Epstein-Barr virus detection in Hodgkin's and Reed-Sternberg cells.

EPSTEIN BARR VIRUS LMP-1 POSITIVITY IN HODGKIN LYMPHOMA SUBTYPES, IN KHYBER PAKHTUNKHWA PROVINCE OF PAKISTAN

It has been suggested that the pro-inflammatory cytokines from EBV infection contribute to the development of Reed-Sternberg cells.

Simultaneous primary Hodgkin's lymphoma of the sigmoid colon and papillary thyroid carcinoma in an HIV-positive patient

Nevertheless, the confirmation of HL requires morphologic diagnosis of the neoplastic cells with the appropriate cellular background along with the result of immunophenotyping as cells resembling Reed-Sternberg cells can be found in cases of B and T lymphomas, melanomas, sarcoma, and in some reactive conditions such as infectious mononucleosis, which are common in populations across the globe (6).

Hodgkin and Reed-Sternberg cells in bone marrow aspirations of a patient with advanced classical Hodgkin lymphoma

Demonstration of Epstein-Barr virus replication in Reed-Sternberg cells of Hodgkin's disease.

Quantification of gp350/220 Epstein-Barr Virus (EBV) mRNA by real-time reverse transcription-PCR in EBV-associated diseases

Chronic lymphocytic leukemia with coexistent Hodgkin's disease: implications for the origin of the Reed-Sternberg cell.

Reed-Sternberg-Like Cells in Non-Hodgkin Lymphomas

Antibodies to this protein stain the germinal center cells in lymphoid follicles, follicular cells, and interfollicular cells in follicular lymphoma, large B-cell lymphomas, and Burkitt's lymphoma, and the majority of the Reed-Sternberg cells in nodular lymphocyte-predominant Hodgkin's disease.

Rabbit monoclonal antibody for IVD use

Hodgkin's lymphoma caused by Hodgkin cells or reed-Sternberg cells (H-RS) and is one of the white blood cell malignancies.

Hodgkin's lymphoma in sheep parotid lymph node: a case report

7 In order to make the diagnosis of Hodgkin's, multinucleated Reed-Sternberg cells must be present.

Questions for STEP participants

Hodgkin lymphoma (HL) is a malignant proliferation of Reed-Sternberg cells and their variants, Hodgkin cells, in an inflammatory cellular background, and is characterized by a progressive painless enlargement of lymph nodes.

Low apoptotic index & bak expression in EBV-associated childhood classical Hodgkin lymphoma

The absence of Reed-Sternberg cells helps distinguish Kimura's disease from Hodgkin's disease.