Reed-Sternberg cell


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Related to Reed-Sternberg cell: Hodgkin's lymphoma

Reed-Stern·berg cell

(rēd shtĕrn'bĕrg),
large transformed lymphocytes, probably B cell in origin, generally regarded as pathognomonic of Hodgkin disease; a typical cell has a pale-staining acidophilic cytoplasm and one or two large nuclei showing marginal clumping of chromatin and unusually conspicuous deeply acidophilic nucleoli; binucleate Reed-Sternberg cell frequently shows a mirror-image form (mirror-image cell).

Reed-Sternberg cell

(rēd′stûrn′bûrg′)
n.
A large, abnormal, binucleated or multinucleated B cell that is characteristic of Hodgkin lymphoma.

Reed-Stern·berg cell

(rēd-stĕrn'bĕrg sel)
Large transformed lymphocytes, probably B cell in origin, generally regarded as pathognomonic of Hodgkin lymphoma; a typical cell has a pale-staining acidophilic cytoplasm and one or two large nuclei showing marginal clumping of chromatin and unusually conspicuous deeply acidophilic nucleoli; binucleate Reed-Sternberg cells frequently show a mirror-image form (mirror-image cell).
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REED-STERNBERG CELL: Reed-Sternberg cell in Hodgkin Lymphoma

Reed-Sternberg cell

(rēd′stĕrn′bĕrg″)
[Dorothy Reed, U.S. pathologist, 1874–1964; Karl Sternberg, Aust. pathologist, 1872–1935]
A giant, malignant, multinucleated B lymphocyte, the presence of which is the pathologic hallmark of Hodgkin's disease.
See: illustration

Reed-Sternberg cell

A giant cell with paired, mirror-image nuclei that is a diagnostic feature of HODGKIN'S LYMPHOMA and distinguishes it from non-Hodgkin's lymphoma. (Dorothy M. Reed, 1874–1964, American pathologist; and Karl von Sternberg, 1872–1935, Austrian pathologist).
References in periodicals archive ?
Even with appropriate tissue samples, it is important to note that Reed-Sternberg cells only represent a small proportion of the cells in adequate biopsy specimens.
(8,9) How a rising CD4 count increases the risk of HL is unknown, but it is hypothesized that CD4 cells are recruited to Reed-Sternberg cells, and within this microenvironment, CD4 cells secrete growth factors that promote the proliferation and expansion of Reed-Sternberg cells.
Nevertheless, the confirmation of HL requires morphologic diagnosis of the neoplastic cells with the appropriate cellular background along with the result of immunophenotyping as cells resembling Reed-Sternberg cells can be found in cases of B and T lymphomas, melanomas, sarcoma, and in some reactive conditions such as infectious mononucleosis, which are common in populations across the globe (6).
Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription.
Cattaruzza et al., "Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions," International Journal of Cancer, vol.
Miyazato et al., "Expression of CCL28 by Reed-Sternberg cells defines a major subtype of classical Hodgkin's disease with frequent infiltration of eosinophils and/or plasma cells," American Journal of Pathology, vol.
However, those cells that have an imbalance in pro-and anti-apoptotic proteins ratio could represent a transforming event rescuing pre-apoptotic GC B cells from apoptotic stimuli and finally could give rise to Hodgkin and Reed-Sternberg cells. They described bcl-2 and bak cytoplasmic expression in 83.3 and 92 per cent of the cases together with p53 nuclear expression 89.9 per cent of the cases.
These two markers are also commonly expressed by the Reed-Sternberg cells of classical Hodgkin lymphoma, but are uncommonly present in other forms of DLBCL.
In Hodgkin's lymphoma patients, a pathologic evaluation of ovarian tissue can detect Reed-Sternberg cells.
Indeed, EBV is suspected of playing a causative role in Hodgkin's lymphoma: as many as 70% of Reed-Sternberg cells are EBV-positive in HIV-infected patients, whereas, only about one-third of these malignancies in the general population are EBV-positive (26) (see Table).
Prominent features are scattered giant cells resembling Reed-Sternberg cells or virocytes with bizarre, vesicular nuclei, and macronucleoli.
The diagnosis of Hodgkin Lymphoma in lung is based on the recognition of diagnostic Reed-Sternberg cells with reactive cellular infiltrate in the background.