The two Heplisav doses are administered intramuscularly 1 month apart, compared with the 0-, 1-, and 6-month schedule for the two currently approved hepatitis B vaccines, Engerix-B and Recombivax HB
The two Heplisav doses are administered intramuscularly 1 month apart, compared with the 0, 1, and 6 month schedule for the two currently approved hepatitis B vaccines, Engerix-B and Recombivax HB
formulation Recombivax HB
is licensed for children aged 11
The commercial products available are Recombivax HB
(Merck, West Point, PA) and Engerix-B (Smith Kline Beecham, Philadelphia, PA).
A study by MSD on its vaccine, Recombivax HB
, states that induced protective levels of antibody occur in 96% of 1,213 healthy adults when injected into the deltoid muscle.
5-[micro]g and 10-[micro]g doses of Recombivax HB
, James L.
In September, the Food and Drug Administration approved a two adult-dose hepatitis B vaccine schedule for Merck's Recombivax HB
at 0 and 4-6 months for adolescents aged 11-15, and a three pediatric-dose regimen at 0, 12, and 24 months for SmithKline Beecham's Engerix for 5- to 16-year-olds.
Middleman believes the findings of the study would be applicable as well to the other hepatitis B vaccine, Recombivax HB
said the company is accelerating production of Comvax, and will offer thimerosal-free pediatric single-dose Recombivax HB