Some of the major DNA vaccines include GlaxoSmithKline's Engerix-B, Twinrix, and Fendrix; Merck's Gardasil, and Recombivax HB
; Protein Sciences Corporation's Flublok, etc.
Hepatitis (Recombivax HB
, Havrix, Engerix-B), influenza (Fluarix, Fluzone, FluMist), polio (IPOL), malaria (RTSS), tuberculosis (BCG) are the some examples of anti-infective vaccines available in market.
Two are single-antigen vaccines--Engerix-B (GlaxoSmithKline Biologicals) and Recombivax HB
(Merck & Co.)--and both can be used starting at birth.
of India Heberbiovac HB Hepatitis B CIGB-Heber Biotec Hepavax-Gene Hepatitis B Crucell Recombivax HB
Hepatitis B Merck Revac-B Hepatitis B Bharat Biotech International Shanvac-B Hepatitis B Shanta Biotechnics Gardasil HPV Merck Cervarix HPV GSK Inflexal V Influenza Crucell HeberNasvac Hepatitis B The Cuban regulatory authorities Hecolin Hepatitis B Xiamen Innovax Biotech Vaccine Name Expression System Epaxal Cell-free GenHevac B Mammalian (CHO cells) Bio-Hep-B Mammalian (CHO cells) DTP-Hep B Yeast (P.
The two Heplisav doses are administered intramuscularly 1 month apart, compared with the 0-, 1-, and 6-month schedule for the two currently approved hepatitis B vaccines, Engerix-B and Recombivax HB
. The two phase III noninferiority studies of healthy adults aged 1870 years compared immune response to vaccination with Heplisav (administered at 0 and 1 months, with a saline placebo administered at 6 months) in 3,778 adults, and with Engerix-B (administered at 0, 1, and 6 months) in 1,089 people.
The two Heplisav doses are administered intramuscularly 1 month apart, compared with the 0, 1, and 6 month schedule for the two currently approved hepatitis B vaccines, Engerix-B and Recombivax HB
formulation Recombivax HB
is licensed for children aged 11
The most notable difference in the new guidelines is the recommendation that patients who do not respond to an initial series be revaccinated with a second 3-dose (Recombivax HB
) or 4-dose (Energix-B[R], Smithkline Beecham Pharmaceuticals, Philadelphia, PA) course.
A single-antigen, preservative-free hepatitis B vaccine (Recombivax HB
, pediatric) from Merck Vaccine Division (West Point, Pennsylvania) had earlier received similar approval .
2 Infants born to HBsAg-negative mothers should receive 2.5 mcg of Merck vaccine (Recombivax HB
) or 10 mcg of SmithKline Beecham (SB) vaccine (Energix-B).
The commercial products available are Recombivax HB
(Merck, West Point, PA) and Engerix-B (Smith Kline Beecham, Philadelphia, PA).
A study by MSD on its vaccine, Recombivax HB
, states that induced protective levels of antibody occur in 96% of 1,213 healthy adults when injected into the deltoid muscle. Among 1,149 vaccine recipients (17 to 68 years of age), 96% developed antibody titers between 1 and 2 months after the third dose.