For the homologous recombination pathway
, SOC and ECS were more likely than OCS to have BRCA1(20% and 18% vs.
Immediately after the damage is repaired; often by the homologous recombination pathway
(error free) or the non homologous end join repair pathway (error prone), the gamma 2HAX disappears.
d) Data from a RAD51 protein nuclear foci assay in which the ability for cells to increase the nuclear fraction of RAD51 foci (required for homologous recombination pathway
of DSb repair) at sites of DNA damage is measured using fluorescent microscopy.
Whereas uterine papillary serous carcinoma appears to have a distinct mutation profile, indicating higher activity of the PI3K/PTEN/mTOR pathway, we saw no differences between uterine papillary and ovarian serous carcinomas in alteration of the homologous recombination pathway
," remarked principal investigator Robert Debernardo, MD, Gynecologic Oncologist and Director of Minimally Invasive Surgery at the Cleveland Clinic Ob/Gyn & Women's Health Institute.