nerve growth factor

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nerve growth fac·tor (NGF),

a protein (MW about 27,000) that controls the development of sympathetic postganglionic neurons and possibly also sensory (dorsal root) ganglion cells in mammals; similar factors have been isolated from the venom of several species of snakes; it has been isolated from the submaxillary glands of male mice, and when it is injected into newborn animals, sympathetic ganglia become hyperplastic and hypertrophic; stimulates synthesis of nucleic acids and protein.

nerve growth factor

n. Abbr. NGF
A protein that stimulates the growth of sympathetic and sensory nerve cells.

nerve growth factor (NGF)

a protein whose hormonelike action affects differentiation, growth, and maintenance of neurons.

nerve growth fac·tor

(NGF) (nĕrv grōth fak'tŏr)
A protein secreted by the neuron's target, critical for the survival and maintenance of sympathetic and sensory neurons. The movement of NGF from axon tip to soma is thought to be involved in the long-distance signaling of neurons; binds at least two receptors, which are capable of responding to this growth factor, TrkA (pronounced "Track A") and the LNGFR (for "low affinity nerve growth factor receptor") on the surface of cells.

nerve growth factor

A peptide substance that stimulates growth and differentiation of NEURONES in the sympathetic and sensory nervous system. Nerve growth factor has been found effective in promoting the healing of corneal ulcers due to loss of the sensory innervation of the cornea. Corneal transparency has been restored by this means.

nerve growth factor (NGF)

a protein required for the maintenance of some types of neurone such as sympathetic and sensory neurones. It is produced by some nerve cell target tissues, e.g. smooth muscle. NGF also stimulates the production of nerve cell processes from developing neurones.

Nerve growth factor

A protein resembling insulin that affects growth and maintenance of nerve cells
Mentioned in: Numbness and Tingling

nerve

a macroscopic cordlike structure of the body, comprising a collection of nerve fibers that convey impulses between a part of the central nervous system and some other body region. For a complete list of the named nerves of the body, see Table 14.
Depending on their function, nerves are known as sensory, motor or mixed. Sensory nerves, or afferent nerves, carry information from the periphery of the body to the brain and spinal cord. Sensations of heat, cold, pressure and pain are conveyed by the sensory nerves. Motor nerves, or efferent nerves, transmit impulses from the brain and spinal cord to the periphery, especially the muscles. Mixed nerves are composed of both motor and sensory fibers, and transmit messages in both directions.
Together, the nerves make up the peripheral nervous system, as distinguished from the central nervous system, which consists of the brain and spinal cord. There are 12 pairs of cranial nerves, which carry messages to and from the brain. Spinal nerves arise from the spinal cord and pass out between the vertebrae. The various nerve fibers and cells that make up the autonomic nervous system innervate the glands, heart, blood vessels and involuntary muscles of the internal organs. For a complete list of nerves, see Table 14.

accelerator n's
the cardiac sympathetic nerves, which, when stimulated, accelerate the heart rate.
nerve biopsy
specimens taken from representative nerves by separation and removal of fascicles may provide useful information in the investigation of neuromuscular disorders or neuropathies. Consideration must be given to any resulting motor or sensory deficits that might result from the procedure. In dogs, the common peroneal, ulnar and tibial nerves are the usual sources.
nerve cuff
device used in the surgical repair of nerves to protect the site of anastomosis from an in-growth of connective tissue and to promote linear regeneration of neural elements.
depressor nerve
1. an inhibitory nerve whose stimulation depresses a motor center.
2. a nerve that lessens activity of an organ.
dermal nerve network
the organization of sensory nerve fibers to the dorsal root ganglia found in the dermis.
nerve endings
comprise afferent and efferent endings. Afferent endings transform sensations into acceptable stimuli by the CNS; include diffuse-free endings, free, modified free or encapsulated (e.g. tactile corpuscles, Krause's endbulbs, Golgi-Mazzoni corpuscles, genital corpuscles, lamellated corpuscles, Herbst corpuscles, Uffini corpuscles). Efferent endings transform nerve impulses into stimuli delivered to effector end organs; they include neuromuscular spindles, Golgi tendon organs.
encapsulated nerve endings
see nerve endings (above).
excitor nerve
one that transmits impulses resulting in an increase in functional activity.
excitoreflex nerve
a visceral nerve that produces reflex action.
nerve fiber
a process of a neuron, especially the long slender axon which conducts nerve impulses away from the cell. It may be medullated or nonmedullated.
free nerve endings
see nerve endings (above).
fusimotor n's
those that innervate the intrafusal fibers of the muscle spindle.
gangliated nerve
any nerve of the sympathetic nervous system. Called also ganglionated.
nerve gas
organophosphorus compounds specially selected for their toxicity to humans and used in chemical warfare.
nerve growth factor
a protein dimer composed of two identical polypeptide chains secreted by nerve cells and necessary for the growth and survival of certain classes of nerve cells during development.
nerve impulses
the physicochemical change in a nerve fiber's membrane which is caused by stimulation, e.g. from a stretch receptor, and which transmits a record of the sensation, or, in another case, of a motor instruction to an effector organ.
inhibitory nerve
one that transmits impulses resulting in a decrease in functional activity.
medullated nerve
myelinated nerve.
modified free nerve endings
see nerve endings (above).
myelinated nerve
one whose axons are encased in a myelin sheath.
pelvic n's
nerves of the parasympathetic outflow. See Table 14.
peripheral nerve
any nerve outside the central nervous system. Injury to a nerve causes pain initially and if tissue is destroyed, loss of function follows; signs are weakness or paralysis, atrophy, lower temperature and depressed reflexes.
pilomotor n's
those that supply the arrector muscles of hair.
pressor nerve
an afferent nerve whose impulses stimulate a vasomotor center and increases intravascular tension.
retinal nerve fiber layer
layer number 9 of the retina; axons of ganglion cells, make up bundles of nerve fibers and pass to the optic disk and lamina cribrosa; from there on they become the optic nerve.
secretory nerve
an efferent nerve whose stimulation increases glandular activity.
nerve sheath
nerve sheath tumor
neurilemmoma or schwannoma.
somatic n's
the sensory and motor nerves supplying skeletal muscle and somatic tissues.
somatic afferent n's
sensory neurons whose cell bodies reside in spinal and cranial nerve ganglia.
somatic efferent n's
motor neurons originating in ventral gray columns of the spinal cord and certain parts of the brain and are connected to striated muscles derived from embryonic somites.
spinal nerve
a segmental nerve which consists of afferent and efferent axons from its dorsal and ventral roots.
splanchnic n's
those of the blood vessels and viscera, especially the visceral branches of the thoracic, lumbar and pelvic parts of the sympathetic trunks.
nerve stimulator
an electrical device used to deliver a short stimulus to a peripheral nerve as a test of its function. It can be used to assess the effects of a neuromuscular blocking agent during clinical anesthesia.
sudomotor n's
those that innervate the sweat glands.
sympathetic n's
1. see sympathetic trunk.
2. any nerve of the sympathetic nervous system.
nerve terminal
nerve ending.
trophic nerve
one concerned with regulation of nutrition.
nerve trunk
the main body of a nerve; subsequently divides into branches.
unmyelinated nerve
one whose axons are not encased in a myelin sheath.
vasoconstrictor nerve
one whose stimulation causes narrowing of blood vessels.
vasodilator nerve
one whose stimulation causes dilatation of blood vessels.
vasomotor nerve
one concerned in controlling the caliber of vessels, whether as a vasoconstrictor or vasodilator.
vasosensory nerve
any nerve supplying sensory fibers to the vessels.
visceral afferent n's
nerves with cell bodies in spinal and cranial ganglia and which provide sensory innervation to thoracic and abdominal tissues.
visceral efferent n's
the parasympathetic component of the autonomic nervous system.
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