epidermal growth factor receptor(redirected from Receptor, epidermal growth factor)
epidermal growth factor receptor (EGFR),[MIM*131550]
receptor often upregulated in epithelial tumors.
EGFRA gene on chromosome 7p12 that encodes epidermal growth factor, a transmembrane glycoprotein of the protein kinase superfamily, which is a receptor for members of the epidermal growth factor family. Binding of the protein to a ligand induces receptor dimerisation and tyrosine autophosphorylation and leads to cell proliferation.
EGFR mutations are associated with lung cancer.
ep·i·der·mal growth fac·tor re·cep·tor(EGFR) (ep'i-dĕr'măl grōth fak'tŏr rĕ-sep'tŏr)
Receptor often upregulated in epithelial tumors.