epidermal growth factor receptor

(redirected from Receptor, epidermal growth factor)

epidermal growth factor receptor (EGFR),

receptor often upregulated in epithelial tumors.


A gene on chromosome 7p12 that encodes epidermal growth factor, a transmembrane glycoprotein of the protein kinase superfamily, which is a receptor for members of the epidermal growth factor family. Binding of the protein to a ligand induces receptor dimerisation and tyrosine autophosphorylation and leads to cell proliferation.

Molecular pathology
EGFR mutations are associated with lung cancer.

ep·i·der·mal growth fac·tor re·cep·tor

(EGFR) (ep'i-dĕr'măl grōth fak'tŏr rĕ-sep'tŏr)
Receptor often upregulated in epithelial tumors.
References in periodicals archive ?
The highly expressed growth factor receptor genes, meanwhile, were platelet-derived growth factor receptor-like protein, platelet-derived growth factor receptor (beta polypeptide), autocrine motility factor receptor, transforming growth factor beta type 2 receptor, epidermal growth factor receptor, and insulin-like growth factor 2 receptor (IGF2R).
In the case of epidermal growth factor receptor, epidermal growth factor stimulates its receptor to autophosphorylate tyrosine sites in the cytoplasmic portion of the receptor.[16] This in turn stimulates activation of guanine nucleotide exchange factors, which promote the formation of the active guanosine triphosphate (GTP)-bound form of Ras.
JuneBiedler of Memorial Sloan-Kettering Cancer Center in New York studied 12 cell lines from mouse, human and hamster cancers and found that not only p-glycoprotein but also another protein, sorcin, and a cell membrane receptor, epidermal growth factor, were present in high concentrations.

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