Adriamycin's mechanism of cardiotoxicity involves reactive oxygen
and nitrogen species generation, a phenomenon that is reduced by free radical scavengers such as these plant-derived compounds.
They over express certain proteins, including one called DJ1, that help them survive attack by reactive oxygen
species that otherwise might kill them, said study author, Oleh Taratula.
They tested the radio-protective effect of these compounds against gamma-radiation in terms of reducing levels of reactive oxygen
species generated in skin cells by clinical relevance dose of gamma ray in the laboratory and in terms of the damage to the genetic material DNA, specifically double strand breaks in laboratory samples of human skin cells (keratinocytes).
Highly reactive oxygen
molecules are produced as a by-product of this process.
Superoxide, a type of reactive oxygen
species made of two oxygen atoms, can blast open clusters of iron and sulfur found on certain proteins.
However, this study suggests that using resveratrol to remove the reactive oxygen
species may blunt the benefits of exercise.
He is critical of claims made for antioxidant supplements in general, and proposes that depletion of reactive oxygen
species in this way may actually be harmful for two reasons.
In Angewandte Chemie, researchers have now proposed a new approach for supplemental treatment: Ceria nanoparticles could trap the reactive oxygen
compounds that result from ischemia and cause cells to die.
The study by the Brazilian researchers found that neural cells derived from inducted pluripotent stem cells (iPSCs) generated from skin fibroblasts of a schizophrenic patient demonstrated a twofold increase in extra-mitochondrial oxygen consumption as well as elevated levels of reactive oxygen
aureus with isoconazole nitrate resulted in the accumulation of reactive oxygen
species reaching its maximum after 60 minutes.
Photodynamic therapy uses molecules which, when irradiated with light, cause irreparable damage to cells by creating toxic forms of oxygen, called reactive oxygen
Oxidative stress and the creation of reactive oxygen
species (ROS) is a factor in many diseases.