reactive lymphocyte

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atypical lymphocyte

An enlarged dysmorphic lymphocyte characterised by an often irregular monocyte-like nucleus that may stretch the length of the cell, with chromatin strands that parallel the length of the nucleus; nucleoli and azurophilic granules may be present. Atypical lymphocytes are seen in various non-neoplastic conditions, classically in infectious mononucleosis (<20% of circulating WBCs are atypical), toxoplasmosis, CMV infection and viral hepatitis.

ALs were formerly (and arbitrarily) grouped into three types, now of historic interest:
• Type I—Monocyoid or prolymphocytic kidney-shaped or lobulated nuclei, with densely homogeneous hypergranular chromatin, more similar to mature lymphocytes than plasma cells; cytoplasm is bubbly, eccentric and basophilic.
• Type II—Cytoplasmic radiations from the nucleus (“ballerina skirt” cells); cells have 1+ nucleoli; chromatin is less dense and cytoplasm is less foamy than type I, contains some azurophilic granules, is basophilic, and “scallops” around RBCs.
• Type III—Nuclei are coarse, span the cell’s breadth, have clumped red-to-purple chromatin with 1–4 nucleoli; the cytoplasm is abundant, basophilic, and “scallops” around adjacent RBCs. ALs have abundant cytoplasm, with basophilic condensations where they abut RBCs; mitochondria are large, numerous and scattered throughout the cytoplasm.

reactive lymphocyte

A lymphocyte that has become enlarged as a result of stimulation by antigens. Such a lymphocyte can be over 30 µm in diameter and of varying sizes and shapes.
See also: lymphocyte
References in periodicals archive ?
CD45 was positive in most of the reactive lymphocytes, whereas CD3 was positive in all reactive T lymphocytes.
Caption: Figure 3: Hematoxylin-eosin stain of a section through the center of the nodule (a) shows numerous confluent lymphoid follicles composed of large, reactive lymphocytes with intervening smaller lymphoid cells.
FNAC-10x Power Shows Groups of Pleomorphic Epithelial Cells with Reactive Lymphocytes
These cells release factors that induce the accumulation of reactive lymphocytes, macrophages, and granulocytes, which typically make up greater than 90% of the tumor cellularity.
The cells were admixed with reactive lymphocytes. The above features are suggestive of benign thymoma.
(15) Because our protocol for FICTION was somewhat different from the protocols previously used, it is important to note that additional BCL6 signals consistent with amplification were not seen in any small, reactive lymphocytes in the NLPHL cases or in any case of FH.
1 Viral meningitis Suspected LCM 2 Lymphocytic meningitis Suspected LCM 3 Lymphocytic meningitis Suspected LCM 4 Lymphocytic meningitis Suspected LCM 5 Tuberculosis meningitis Miscoded 6 Lyme encephalitis Miscoded 7 Lymphocele Miscoded 8 Lymphocytic cholitis Miscoded 9 Lymphocytic leukemia Miscoded 10 Lymphocytic leukemia Miscoded 11 Atypical lymphocytes Miscoded 12 Reactive lymphocytes Miscoded 13 Charcot foot anomaly Miscoded 14 Tuberculosis Miscoded * Diagnosis was the first listed or most clinically relevant written diagnosis from the medical record.
Abnormal cells, band forms, and reactive lymphocytes are easily detected and numbers estimated when the slide is scanned by an expert.
The development of the immune system, including the development of the repertoire of reactive lymphocytes that will exist in postnatal life, begins prenatally.
Comparison of cytograms from hematology systems with the those generated by the flow cytometer assists in assuring that larger reactive lymphocytes, particularly those with granules, are included in the correct analytic gate.
Fine-needle aspiration slides were reviewed in 2 cases.[14] The specimens were cellular with follicular cells arranged in 3-dimensional groups, papillary fragments, and single cells in the background of numerous reactive lymphocytes (Figure 1, A-C).

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