rate-determining step

(redirected from Rate-limiting enzyme)
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rate-determining step

The chemical reaction in a series of sequential reactions that takes the longest to occur.
See also: step
References in periodicals archive ?
[ClickPress, Thu Jul 04 2019] 6-Azauracil inhibits IMP dehydrogenase (IMPDH) the rate-limiting enzyme in de novo GTP synthesis.
[UKPRwire, Thu Jul 04 2019] 6-Azauracil inhibits IMP dehydrogenase (IMPDH) the rate-limiting enzyme in de novo GTP synthesis.
[9] Hexokinase is a very important glycolytic enzyme and also rate-limiting enzyme, determines the rate of glucose utilization by the cells.
FAS is the rate-limiting enzyme in the last step of de novo synthesis of the long-chain fatty acids in animals, catalyzes Acetyl-CoA and Maloney-CoA to synthesize the fatty acid [37].
Iron and Magnesium: Iron as a cofactor for tyrosine hydroxylase, the rate-limiting enzyme of monoamine synthesis, is directly involved in the regulation of dopamine and noradrenaline synthesis.
This activity was 36 to 44 times lower than the maximal activity of encapsulated ALD, (i.e., the rate-limiting enzyme in the ethanol-metabolizing pathway) and 1560-2140 times lower than the maximal activity of encapsulated ADH.
Ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis, plays an important role in polyamine generation, whereas spermidine/spermine[N.sup.1]-acetyltransferase (SSAT) is the rate-limiting enzyme of catabolism (Figure 1).
D6-Desaturase enzyme is the rate-limiting enzyme involved in HUFAs biosynthesis, which is responsible for the first step of the desaturation/elongation process in HUFAs synthesis.
It is an antigen-binding fragment of a humanised, monoclonal antibody directed against complement factor D, which is a rate-limiting enzyme involved in the activation of the alternative complement pathway, a component of the immune system.
Comment: Biotin is a cofactor for acetyl-CoA carboxylase, a potentially rate-limiting enzyme in myelin synthesis.
In rare cases, these tumors may not produce any catecholamines, owing to the lack of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis.
Mice lacking the gene encoding brain tryptophan hydroxylase 2 (Tph2-/-), the initial and rate-limiting enzyme in the synthesis of serotonin, were tested in numerous behavioral assays that are well known for their utility in modeling human neuropsychiatric diseases.

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