[ClickPress, Thu Jul 04 2019] 6-Azauracil inhibits IMP dehydrogenase (IMPDH) the
rate-limiting enzyme in de novo GTP synthesis.
[9] Hexokinase is a very important glycolytic enzyme and also
rate-limiting enzyme, determines the rate of glucose utilization by the cells.
FAS is the
rate-limiting enzyme in the last step of de novo synthesis of the long-chain fatty acids in animals, catalyzes Acetyl-CoA and Maloney-CoA to synthesize the fatty acid [37].
Iron and Magnesium: Iron as a cofactor for tyrosine hydroxylase, the
rate-limiting enzyme of monoamine synthesis, is directly involved in the regulation of dopamine and noradrenaline synthesis.
This activity was 36 to 44 times lower than the maximal activity of encapsulated ALD, (i.e., the
rate-limiting enzyme in the ethanol-metabolizing pathway) and 1560-2140 times lower than the maximal activity of encapsulated ADH.
Ornithine decarboxylase (ODC), the
rate-limiting enzyme of polyamine biosynthesis, plays an important role in polyamine generation, whereas spermidine/spermine[N.sup.1]-acetyltransferase (SSAT) is the
rate-limiting enzyme of catabolism (Figure 1).
D6-Desaturase enzyme is the
rate-limiting enzyme involved in HUFAs biosynthesis, which is responsible for the first step of the desaturation/elongation process in HUFAs synthesis.
It is an antigen-binding fragment of a humanised, monoclonal antibody directed against complement factor D, which is a
rate-limiting enzyme involved in the activation of the alternative complement pathway, a component of the immune system.
Comment: Biotin is a cofactor for acetyl-CoA carboxylase, a potentially
rate-limiting enzyme in myelin synthesis.
In rare cases, these tumors may not produce any catecholamines, owing to the lack of tyrosine hydroxylase, the
rate-limiting enzyme in catecholamine biosynthesis.
Mice lacking the gene encoding brain tryptophan hydroxylase 2 (Tph2-/-), the initial and
rate-limiting enzyme in the synthesis of serotonin, were tested in numerous behavioral assays that are well known for their utility in modeling human neuropsychiatric diseases.