have long been the focus of cancer research because of their role as 'on/off switch' signaling pathways that control cell division and failure to die like normal, healthy cells do.
Treatment of human placental tissue with LPS, TNF-[alpha], or IL-1[beta] significantly increased Ras protein
expression (Figure 1(c)) and activity (Figure 1(d)).
first described in murine sarcoma virus, Harvey and Kirsten (Kirsten rat sarcoma oncogene).
Tsutsumi et al., "Mouse dexamethasone-induced RAS protein
1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus," Molecular Brain Research, vol.
Professionals can then administer monthly boosters of the vaccine to generate an immune response against mutant RAS protein
. An immune response is the ability of certain blood cells (lymphocytes) and their products (antibodies) to attack tumor cells.
The antibody used is a polyclonal anti-ras and recognize all Ras proteins
. Incubation of the blot with the antibody showed that a 21 kDa polypeptide was significantly expressed and increased in the presence of Dex over the 1-4 days period compared to samples extracted the cells grown in the absence of Dex (Fig.
These researchers searched fruitlessly for an antidote to the Ras protein
for almost a decade, recalls Allen Oliff, executive director for cancer research at Merck.
In unfertilized frog eggs, the group observed that human oncogenic ras -- a rare, mutant relative of the normal ras protein
found in cells -- caused breakdown of the envelope surrounding the cell nucleus, indicating the protein induced cell division.
control cell proliferation, and mutation of this protein can lead to cancer in affected individuals.
Researchers report about a newly discovered mechanism by which RAS proteins
, central to cancer signaling, are regulated in their activity and localization.
Researchers established the role of RAS genes and the proteins they encode in human cancer during the 20th century, but they are still working to understand precisely how the RAS proteins
cause cancer and how to intervene therapeutically.