Point mutations of ras oncogenes
are an early event in thyroid tumorigenesis.
At the Keystone meetings, CTI investigators reported that LPAAT-beta function appears to be essential for the ability of the ras oncogene
to enhance the cancer-causing potential of cells.
GRB2 has been a target for many pharmaceutical and biotech R&D programs because it is an activator (or, "adapter protein") for the ras oncogene
The ras oncogene
is an important target involved in many major tumors including colon and bladder.
In addition, Genentech has a broad and intensive effort in preclinical cancer research, including: anti-VEGF, which may inhibit blood vessel growth in tumors; the Ras oncogene
, which may have the potential to stop uncontrolled cell division in certain cancers, such as pancreatic cancer; and thrombopoietin (TPO), which may be useful in treating the platelet destruction caused by irradiation and chemotherapy.
Clinical significance of ras oncogene
activation in human lung cancer.
Kimmelman's research has focused on RAS oncogenes
, one of the most commonly mutated families of cancer-causing genes.
For example, the RAS oncogenes
are regulated by the let-7 family of miRNAs, and MIR155 and MIR gene clusters 17-92 are associated with the MYC [v-myc myelocytomatosis viral oncogene homolog (avian)] oncogene.
Bos JL (1989) Ras oncogenes
in human cancer: a review.
elegans and subsequently in human cells that let-7 regulates the RAS oncogenes
through complementary sites in their RNAs' 3' UTRs.
Analysis of ras oncogenes
in malignant melanoma and precursor lesions: correlation of point mutations with differentiation phenotype.
A dot-blot screening procedure for mutated ras oncogenes
using synthetic oligodeoxynucleotides.