efalizumab

(redirected from Raptiva)

efalizumab

A recombinant, humanized monoclonal antibody to CD11 a used to treat moderate to severe PSORIASIS.
References in periodicals archive ?
A las manifestaciones de violencia fisica, estructural y cultural se anaden a otros tipos de violencia como los definidos recientemente por el activista politico y erudito literario aleman Jean Phillip Reemtsma (2008), quien propone distintivas expresiones de violencia como la locativa, la captiva, la raptiva y la autotelica.
Ng noted that a trial of efalizumab (Raptiva) had terminated because of an increased risk for progressive multifocal leukoencephalopathy.
Finally, [CD4.sup.+] and [CD8.sup.+] T lymphopenia seems to be the primary PML risk factor, following the use of natalizumab (Tysabri; Biogen Idec, Elan Pharmaceuticals), efalizumab (Raptiva; Genentech), and rituximab (Rituxan/MabThera; Genentech, Biogen Idec) for the treatment of multiple sclerosis (MS), Crohn's disease (CD), severe forms of plaque psoriasis, hematologic malignancies, and rheumatoid arthritis (RA) [8].
No cases of herpes zoster occurred in patients on alefacept (Amevive), efalizumab (Raptiva) or adalimumab (Humira), nor was the incidence increased beyond baseline in patients on PUVA, UVB, or etanercept (Enbrel).
withdraw psoriasis drug Raptiva from the market in last year's
(67.) European Medicines Agency recommends suspension of the marketing authorisation of Raptiva (efalizumab).
(19.) Thielen AM, Barde C, Saurat JH: Insiximab- and methotrexate-resistant rebound of psoriasis after discontinuation of efalizumab (Raptiva).
However, risk is a concern because of what happened with the biologic efalizumab (Raptiva), which was taken off the market after three cases (two fatal) of progressive multifocal leukoencephalopathy, a brain infection, were reported in patients treated with the drug for psoriasis.
He serves as a consultant for, or is on the speakers bureau of, 3M/Graceway Pharmaceuticals, Allergan, CollagGenex Pharmaceuticals, Connetics Corp., Dermik/BenzaClin, Galderma, Genentech, Inc., Genentech/ Raptiva, GlaxoSrnithKline, Janssen, MDsConnect.net, Medicis, Novartis Pharmaceuticals Corp., Pedinol Pharmacal, Inc., Roerig-Pfizer, SandoziNovartis, sanofi-aventis, Sirius Laboratories, Stiefel, Westwood-Squibb, and Upjohn.
The Food and Drug Administration has advised prescribers not to initiate Raptiva (efalizumab) treatment for new patients and to engage in discussions with those already on the therapy of avenues for transitioning to alternative treatments.
San Francisco CA) is pulling its psoriasis drug Raptiva from the U.S.