rapidly progressive glomerulonephritis

(redirected from Rapidly progressing glomerulonephritis)


a variety of nephritis characterized by inflammation of the capillary loops in the glomeruli of the kidney. It occurs in acute, subacute, and chronic forms and may be secondary to an infection, especially with the hemolytic streptococcus.
Histologic appearance of acute glomerulonephritis. A, Normal glomerulus. B, Glomerulonephritis. The glomerulus appears hypercellular and the capillaries are narrowed or occluded. From Damjanov, 2000.
diffuse glomerulonephritis a severe form of glomerulonephritis with proliferative changes in more than half the glomeruli, frequently with epithelial crescent formation and necrosis; it is often seen in cases of advanced systemic lupus erythematosus.
IgA glomerulonephritis IgA nephropathy.
lobular glomerulonephritis (membranoproliferative glomerulonephritis) a chronic glomerulonephritis characterized by mesangial cell proliferation and irregular thickening of the glomerular capillary wall. There are two subtypes: Type I is marked by subendothelial deposits and activation of the classic complement pathway. Type II is marked by heavy deposits in the glomerular basement membrane and activation of the alternative complement pathway. Both types occur in older children and young adults and follow a slowly progressing course with irregular remissions ultimately resulting in renal failure.
membranous glomerulonephritis a form characterized by proteinaceous deposits on the glomerular capillary basement membrane or by thickening of the membrane, with circulating antigen-antibody complexes indicating immune complex disease; it may be secondary to any of numerous other conditions. In some cases it may develop into the nephrotic syndrome. Called also membranous nephropathy.
mesangiocapillary glomerulonephritis membranoproliferative glomerulonephritis.
rapidly progressive glomerulonephritis acute glomerulonephritis marked by a rapid progression to end-stage renal disease and histologically by profuse epithelial proliferation, often with epithelial crescents; principal signs are anuria, proteinuria, hematuria, and anemia. Plasmapheresis or high doses of corticosteroids may lead to recovery of renal function.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

rap·id·ly pro·gress·ive glo·mer·u·lo·ne·phri·tis

glomerulonephritis usually presenting insidiously, without preceding streptococcal infection, with increasing renal failure leading to uremia within a few months; at autopsy the kidneys are of normal size, numerous glomerular capsular epithelial crescents are present, and antiglomerular basement membrane antibodies are frequently found.
Farlex Partner Medical Dictionary © Farlex 2012

rapidly progressive glomerulonephritis

Crescentic glomerulonephritis, membranous glomerulonephritis, necrotizing glomerulonephritis Nephrology A type of kidney disease characterized by a rapid loss of renal function, with crescent-shaped deposits in at least 75% of glomeruli seen on kidney biopsies Clinical Acute nephritic syndrome or unexplained renal failure with progression to ESRD; RPGN occurs in ±1/10,000 people, especially between age 40 and 60 Associated diseases Vasculitis, polyarteritis, abscess of internal organ(s), collagen vascular disease–eg, SLE, Henoch-Schönlein purpura, Goodpasture syndrome, IgA nephropathy, membranoproliferative GN, anti-glomerular basement membrane antibody disease, Hx of malignancy or blood or lymphatic disorders, and exposure to hydrocarbon solvents. See End-stage renal disease, Glomerulonephritis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

rapidly progressive glomerulonephritis

Abbreviation: RPGN
Any glomerular disease in which there is rapid loss of renal function, usually with crescent-shaped lesions in more than 50% of the glomeruli.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
A 9-year-old female patient who was being followed up in a continuous ambulatory peritoneal dialysis program (CAPD) for one year because of chronic renal failure (CRF) which developed secondary to rapidly progressing glomerulonephritis presented with complaints including headache, confusion and seizure.
The disorder is manifested by granulomatous necrotizing inflammatory lesions of the upper or lower respiratory tract, or both simultaneously, and usually accompanied by rapidly progressing glomerulonephritis (RPGN).
Manzi suggested that appropriate patients for mycophenolate mofetil treatment are going to be those without rapidly progressing glomerulonephritis, who were excluded from the study, for whom there might be a risk of infection during the treatment, and, maybe more importantly, women of childbearing age.

Full browser ?