randomized controlled trial

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ran·dom·i·zed con·trolled tri·al (RCT),

an epidemiologic experiment in which subjects in a population are allocated randomly into groups, called "experimental" or "study" and "control" groups to receive or not receive an experimental therapeutic or preventive regimen, procedure, maneuver, or intervention.

ran·dom·i·zed con·trolled tri·al

(RCT) (ran'dŏm-īzd kŏn-trōld trī'ăl)
A type of experiment that randomly assigns subjects to various interventions, including a control group, in order to minimize the risk of bias.
See also: control group

randomized controlled trial

Abbreviation: RCT
An experimental study to assess the effects of a particular variable, e.g., a drug or treatment, in which subjects are assigned randomly to an experimental, placebo, or control group. The experimental group receives the drug or procedure; the placebo group's medication is disguised to resemble the drug being investigated. The control group receives nothing. Members of each group are prevented from knowing whether they are receiving active therapy. The researchers gathering the data are also typically blinded to group assignment.

CAUTION!

Although RCTs are an essential element in proving clinical relationships (such as between the use of a new drug and the safe cure of a disease), most RCTs do not enroll enough patients for a long enough time to detect rare events.
See also: trial

trial, randomized controlled (RCT) 

An experimental design used for testing the effectiveness of a new medication or a new therapeutic procedure. Individuals are assigned randomly to a treatment group (experimental therapy) and a control group (placebo or standard therapy) and the outcomes are compared. The trial is strengthened by 'blinding' or masking (single-blind, double-blind or triple-blind study) and cross-over design. RCT is the most accepted scientific method of determining the benefit of a drug or a therapeutic procedure. It represents the best evidence available, which is integrated into the final decision about the management of a condition by healthcare practitioners in what is called evidence-based healthcare. Syn. randomized clinical trial. See sampling; significance; study.
References in periodicals archive ?
Philips remains very confident in the safety and performance of its unique Stellarex low-dose drug-coated balloon (DCB) as a treatment option for patients with PAD, including the durable primary patency (maintained blood flow) demonstrated in complex patients studied in randomized controlled trials at three years.
In 2018, Koushki, et al, who published a systematic review and meta-analysis of 17 randomized controlled trials totaling over 700 participants.
Understanding the gap between efficacy in randomized controlled trials and effectiveness in real-world use of GLP-1 RA and DPP-4 therapies in patients with type 2 diabetes.
The clinical effects of aromatherapy massage on reducing pain for the cancer patients: meta-analysis of randomized controlled trials. Evidence-Based Complementary and Alternative Medicine.
Findings from randomized controlled trials in rural areas of south Asia with high rates of home delivery and neonatal mortality suggest that umbilical cord cleansing with chlorhexidine solution reduces neonatal mortality; however, no research had evaluated the practice in African settings.
All published randomized controlled trials after 1995 with sample size of over 100 and which were printed in English language and had compared the effectiveness of laparoscopic inguinal hernia repair with open mesh inguinal hernia repair were eligible for inclusion.
The effects of calcium supplementation on verified coronary heart disease hospitalization and death in postmenopausal women: a collaborative meta-analysis of randomized controlled trials. J Bone Miner Res.
A new paper published in the International Journal of Epidemiology says that randomized controlled trials (the gold standard method of evaluation) show that few currently available screening tests for major diseases where death is a common outcome have documented reductions in disease-specific mortality.
Randomized controlled trials (RCTs) are considered the gold standard for evaluation of healthcare interventions.
The investigators, from centers in Australia, Denmark and the U.S., undertook a meta-analysis of randomized controlled trials of calcium supplements with or without vitamin D.
RIGOROUS CONTROL CONDITIONS DIMINISH TREATMENT EFFECTS IN WEIGHT LOSS RANDOMIZED CONTROLLED TRIALS. JOHN A.
ERIC Descriptors: Preschool Education; Preschool Children; Achievement Gains; Randomized Controlled Trials; Data Analysis; School Districts; Achievement Tests; Correlation; Program Evaluation; Statistical Analysis; Vocabulary

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