randomized controlled trial

(redirected from Randomized control trial)

ran·dom·i·zed con·trolled tri·al (RCT),

an epidemiologic experiment in which subjects in a population are allocated randomly into groups, called "experimental" or "study" and "control" groups to receive or not receive an experimental therapeutic or preventive regimen, procedure, maneuver, or intervention.

ran·dom·i·zed con·trolled tri·al

(RCT) (ran'dŏm-īzd kŏn-trōld trī'ăl)
A type of experiment that randomly assigns subjects to various interventions, including a control group, in order to minimize the risk of bias.
See also: control group

randomized controlled trial

Abbreviation: RCT
An experimental study to assess the effects of a particular variable, e.g., a drug or treatment, in which subjects are assigned randomly to an experimental, placebo, or control group. The experimental group receives the drug or procedure; the placebo group's medication is disguised to resemble the drug being investigated. The control group receives nothing. Members of each group are prevented from knowing whether they are receiving active therapy. The researchers gathering the data are also typically blinded to group assignment.

CAUTION!

Although RCTs are an essential element in proving clinical relationships (such as between the use of a new drug and the safe cure of a disease), most RCTs do not enroll enough patients for a long enough time to detect rare events.
See also: trial

trial, randomized controlled (RCT) 

An experimental design used for testing the effectiveness of a new medication or a new therapeutic procedure. Individuals are assigned randomly to a treatment group (experimental therapy) and a control group (placebo or standard therapy) and the outcomes are compared. The trial is strengthened by 'blinding' or masking (single-blind, double-blind or triple-blind study) and cross-over design. RCT is the most accepted scientific method of determining the benefit of a drug or a therapeutic procedure. It represents the best evidence available, which is integrated into the final decision about the management of a condition by healthcare practitioners in what is called evidence-based healthcare. Syn. randomized clinical trial. See sampling; significance; study.
References in periodicals archive ?
The randomized control trial was conducted at the Indus Hospital, Karachi, from July 2014 to July 2015, and comprised patients undergoing PCNL.
This paper presents evidence on the amount of classroom variation in gains across various domains of achievement within the Tennessee Voluntary Pre-Kindergarten (TN-VPK) program; the data are taken from the randomized control trial (RCT) design of the TN-VPK evaluation.
To determine whether umbilical cord milking improved newborns' serum levels of hemoglobin and the iron-storing protein ferritin, researchers conducted a randomized control trial among 200 term and near-term infants born at one North India teaching hospital between April 2010 and September 2011.
Cellular monitoring works because of evidence from Randomized Control Trial evaluations; but if a similar logic holds for service provision, then there is much more potential to create positive change.
"Cellular monitoring works because of evidence from Randomized Control Trial evaluations; but if a similar logic holds for service provision, then there is much more potential to create positive change." He will also attempt a rigorous Randomized Control Trial evaluation in collaboration with Dr.
"The Importance of Beta, the Type II Error, and Sample Size in the Design and Interpretation of the Randomized Control Trial. Survey of 71 "Negative Trials." New England Journal of Medicine 299(13):690-4, Sept.
The Importance of Beta, The Type II Error and Sample Size in the Design and Interpretation of the Randomized Control Trial. New England Journal of Medicine 1979, 299:690-694.
This study interleaves a randomized control trial (RCT) design and an age-cutoff regression discontinuity (RD) design to evaluate the effectiveness of the TN-VPK program.
The study used a randomized control trial (RCT) design (blocking on classrooms) to investigate the ROOTS intervention when implemented under rigorous experimental conditions.
Researchers conducted a randomized control trial at two sites for both studies.
Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials. Nutrients.
(1403945004 $26.95) gathers evidence on placebos, randomized control trials, and more to conclude alternative therapies could indeed provide new paths to help chronic disease sufferers.

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