cao wu

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cao wu

Chinese herbal medicine
The root of Aconitum kusnezoffi, said to be anti-inflammatory, analgesic and cardiotonic; it has been used for musculoskeletal disorders.

Toxicity
Cao wu contains the highly toxic C19 diterpenoid alkaloids of aconite, mesaconitine and hypaconite; the signs and symptoms are those of aconite poisoning, which may cause death due to ventricular arrhythmias in the first 24 hours.
 
Management
Supportive.
References in periodicals archive ?
Toxic herbs such as Radix aconiti lateralis praeparata (Fu zi), Rhizoma pinelliae (Ban xia) and Cinnabaris (Zhu sha) are top 3 herbs that most frequently used in combination with licorice.
That is to say, when licorice was used in combination with some toxic herbs such as Radix aconiti lateralis praeparata (Fu zi), Rhizoma pinelliae (Ban xia) and Cinnabaris (Zhu sha), the toxicity of these herbs might be attenuate by licorice.
Radix aconiti lateralis praeparata (Fu zi) is the most commonly used toxic herb in Chinese Formulae Database
As shown in Table 2, the most frequently used toxic herbs was Radix aconiti lateralis praeparata (Fu zi), followed by Rhizoma pinelliae (Ban xia), Cinnabaris (Zhu sha), etc.
Rhizoma pinelliae (Ban xia), Radix aconiti lateralis praeparata (Fu zi), Cinnabaris (Zhu sha) are top 3 most frequently used herbs that combined with licorice
Radix aconiti lateralis praeparata (Fu zi), Cinnabaris (Zhu sha) were most frequently used in combination with licorice among all of the recorded toxic herbs, which showed that licorice might reduce the toxic of commonly used toxic herbs.
For example, Radix aconiti lateralis praeparata was classified to be "hot" herbs which are likely to cause systemic numbness, a reduction in reflexes, difficulty in swallowing, etc.
According to the Chinese Prescription Database analysis of Radix Aconiti Lateralis Praeparata, out of a total of 8111 prescriptions, 29.
The formula is composed of five herbs including Caulis Sinomenii, Radix Aconiti lateralis Preparata, Rhizoma Curcumae longae, Radix Paeoniae albae, and Cortex Moutan.
In addition, Radix Aconiti lateralis Preparata contains very small amounts of the aconitum alkaloids, such as aconitine, mesaconitine, and hypaconitine, which are highly toxic but can be hydrolyzed to the more active but less toxic alkaloids, including benzoylaconine, benzoylmesaconine, and benzoylhypaconine that have significant anti-inflammatory and antinociceptive activities (Suzuki et al.
Radix Aconiti lateralis Preparata and Rhizoma Curcumae longae, cultivated in the Good Agricultural Practice (GAP) bases at Jiangyou Country and Shuangliu Country of Chengdu City, respectively, were purchased in the wholesale market of Chengdu City, Shichuan Province, China.
Caulis Sinomenii (25 g), Radix Aconiti lateralis Preparata (15 g), and Radix Paeoniae alba (30 g) were refluxed together with 80% ethanol and concentrated to produce Extract 1.