The primary objective of this study sponsored by Ligand was to obtain directional guidance from hospital specialists involved in contrast-enhanced angiography, and to learn of perceptions, practices and unmet needs regarding radiocontrast agents
used for angiography.
Gadolinium (Gd)-based contrast agents have not proved safer than the iodinated hydrophilic radiocontrast agents
used in X-ray radiography or computed tomography; and because these gadolinium contrast agents pass the blood-brain barrier, increased awareness has focused on their toxicity.
Effects of saline, mannitol, and furosemide on acute decreases in renal function induced by radiocontrast agents
. N Engl J Med 1994; 331(21): 1416-20.
The prevalence of HSRs to different IV-iron preparations is very low, a feature shared only with the safest radiocontrast agents
. (3) A meta-analysis done on the safety of intravenous iron preparations showed that there can be infusion reactions with intravenous iron, but there was no increase in the serious adverse effects.
This list of medications includes antibiotics, nutritional solutions for intensive care units, drugs used for muscle extension, medicines for incubators, other drugs for the respiratory system, newborns, kidney supplements, and radiocontrast agents
, as well as treatment drugs for patients with thalassaemia, said Ziada.
Russo et al., "Differential activation of signaling pathways by low-osmolar and Iso-osmolar radiocontrast agents
in human renal tubular cells," Journal of Cellular Biochemistry, vol.
Mechanisms, such as direct toxicity, hemodynamic changes, and tubular obstruction, are thought to play role in the pathophysiology of acute renal failure due to radiocontrast agents
Intravenous iodinated radiocontrast agents
labelled with gadolinium are used as contrast media in patients undergoing MRI scans.
We have seen that ROS play an important role in the nephrotoxicity by iodinated radiocontrast agents
. Thus, it has been thought that antioxidants could be useful in preventing CIN.
Hizoh, "The cytotoxicity of iodinated radiocontrast agents
on renal cells in vitro" Investigative Radiology, vol.
, which have been used in common daily clinical practice, can cause severe vasculitic syndrome and acute renal failure and, LV may be confused with diabetic foot ulcer.