RAD17

(redirected from Rad24)

RAD17

A gene on chromosome 5q13 which encodes a protein that binds to chromatin before DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. RAD17 recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage. RAD17 phosphorylation is required for the DNA-damage-induced cell cycle G2 arrest, and is a critical early event during checkpoint signalling in DNA-damaged cells.
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Protein function S.cerevisiae S.pombe Xenopus Mammals Sensors Rad24 Rad17 Rad17 Rad17 RFC-like Ddc1 Rad9 Rad9 Rad9 PCNA-like Mec3 Hus1 Hus1 Hus1 Rad17 Rad1 Rad1 Rad1 P13-Kinases (PIKK) Tel1 Tel1 ATM ATM Med Rad3 ATR ATR PIKK binding partner Ddc2 Rad26 ???