Differential control of growth, cell cycle progression, and expression of NF-KB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinease herb Rabdosia rubescens.
Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-KB signal pathways.
Rabdosia rubescens is a Chinese medicinal herb which has been approved by State Food and Drug Administration of China for the treatment of inflammation such as acute tonsillitis, sphagitis, astomatitis and gingivitis.
Over the past thirty years, considerable in vitro and animal studies have been performed to determine the active ingredient of Rabdosia rubescens and the precise mechanism responsible for its antitumor activity.
It is found that oridonin (Figure 1), an entkaurane diterpenoid derived from the herbal Rabdosia rubescens inhibit the proliferation of human nasopharyngeal carcinoma CNE2 cells , human gastric cancer MKN45 cells , U937 cells , HeLa cells , murine fibrosarcoma L929 cells , human laryngeal carcinoma HEp-2 cells , HT1080 cells , human hepatocelluar carcinoma BEL-7402 cells , human melanoma A375-S2 cells , leukemia K562 cells  and some other tumor cells.
Oridonin is extracted and purified from Rabdosia rubescens, one of the most important traditional Chinese herbs commonly used in China nowadays.
Chen S, Liu J, Zhang H (2009) Efficacy of rabdosia rubescens in the treatment of gingivitis.
Hsieh TC, Wijeratne EK, Liang JY, Gunatilaka AL, Wu JM (2005) Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens.