Four pivotal trials in non-human primates (NHPs) and two pivotal trials in rabbits demonstrated that TPOXX significantly reduced both mortality and viral load in NHP infected with monkeypox virus (MPXV) and in rabbits infected with rabbitpox virus
. The results of these studies were published in the July 5, 2018 issue of the New England Journal of Medicine.
BPSV, bovine papular stomatitis virus; CPXV, cowpox virus; RPXV, rabbitpox virus
; MPXV, monkeypox virus; ORFV, for virus; PCPXV, pseudocowpox virus; PVNZ, parapoxvirus of red deer in New Zealand; SPV, sealpox virus; VARV, variola virus.
from Utrecht has a unique deletion of only 2 residues (254, 255); VACV-3737 and VACV-Malbran share a 5--amino acid deletion (245-249).