RAB6A

(redirected from Rab GTPase)

RAB6A

A gene on chromosome 11q13.3 that encodes a member of the Rab subfamily of Ras-related small GTPases, which directs membrane traffic from the Golgi apparatus towards the endoplasmic reticulum.
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However, the Rab GTPase responsible for myosin-V recruitment to axoplasmic vesicles in the squid giant axon has not been determined, although our earlier data showed Rab GTPases are required for myosin-V-mediated vesicle transport.
The Rab GTPase responsible for myosin V recruitment to axoplasmic vesicles in the squid giant axon has not been determined, although Rab 3a is known Io be associated with synaptic vesicles in squid brain (8).
To identify the Rab GTPase involved in myosin-V/kinesin binding to axoplasmic vesicles, and to identify all binding partners of the hetero-motor complex, we used a recombinant glutathione S-transferase (GST)-labeled globular tail domain of myosin-V (GST-GTD) and a GST-labeled Rab GDP dissociation inhibitor (GST-GDI) in motility and affinity isolation experiments.
Additionally, Rab GTPases have been implicated in various human diseases, ranging from diabetes to cancer.
The 12 chapters cover well-characterized Ypts/Rabs involved in both exocytic and endocytic pathways as well as newly identified and uncharacterized Rab GTPases.