RYR1

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RYR1

A gene on chromosome 19q13.1 that encodes a ryanodine receptor found in skeletal muscle, which acts as a calcium channel connecting the sarcoplasmic reticulum and transverse tubules.

Molecular pathology
RYR1 mutations are linked to malignant hyperthermia susceptibility, central core disease and minicore myopathy with external ophthalmoplegia.
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References in periodicals archive ?
Hidalgo, "Aging impairs hippocampal-dependent recognition memory and LTP and prevents the associated RyR up-regulation," Frontiers in Aging Neuroscience, vol.
Winslow, "Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model," Journal of Molecular and Cellular Cardiology, vol.
The effect of BPA on myocyte [Ca.sup.2+] handling was mediated by characteristic impact on the phosphorylation of two key [Ca.sup.2+] handling proteins, RyR and PLN (Gao et al.
Two positive controls were used: RYR commercial MFP and atorvastatin as the most common hypocholesterolemic medication available in the market.
Bioactive compounds found in RYR complement monacolin-K's lipid-lowering effects, including unsaturated fats.
Secondary endpoints revealed a 21% decin LDL levels in the RYR group (P=0.0001) and a 12% decin triglyceride levels (P=0.003) compared with trivial declines in the placebo group.
The issue with supplements such as RYR is that, since they are not regulated by the FDA, there is not a requirement to standardize the amount of the active ingredient in any given product.